Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival

BACKGROUND: Intrinsic and acquired resistance to drug therapies remains a challenge for malignant melanoma patients. Intratumoral heterogeneities within the tumor microenvironment contribute additional complexity to the determinants of drug efficacy and acquired resistance. METHODS: We use 3D biomim...

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Detalles Bibliográficos
Autores principales: Afasizheva, Anna, Devine, Alexus, Tillman, Heather, Fung, King Leung, Vieira, Wilfred D., Blehm, Benjamin H., Kotobuki, Yorihisa, Busby, Ben, Chen, Emily I., Tanner, Kandice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779217/
https://www.ncbi.nlm.nih.gov/pubmed/26944546
http://dx.doi.org/10.1186/s12885-016-2211-7

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