Development of a Cost-effective Ovine Polyclonal Antibody-Based Product, EBOTAb, to Treat Ebola Virus Infection

The highly glycosylated glycoprotein spike of Ebola virus (EBOV-GP(1,2)) is the primary target of the humoral host response. Recombinant EBOV-GP ectodomain (EBOV-GP(1,2ecto)) expressed in mammalian cells was used to immunize sheep and elicited a robust immune response and produced high titers of hig...

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Detalles Bibliográficos
Autores principales: Dowall, Stuart David, Callan, Jo, Zeltina, Antra, Al-Abdulla, Ibrahim, Strecker, Thomas, Fehling, Sarah K., Krähling, Verena, Bosworth, Andrew, Rayner, Emma, Taylor, Irene, Charlton, Sue, Landon, John, Cameron, Ian, Hewson, Roger, Nasidi, Abdulsalami, Bowden, Thomas A., Carroll, Miles W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles and Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779302/
https://www.ncbi.nlm.nih.gov/pubmed/26715676
http://dx.doi.org/10.1093/infdis/jiv565

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