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Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction
AIM: The aim of this study was to evaluate biochemical parameters in serum of women with preeclampsia and IUGR. MATERIAL AND METHODS: A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AVICENA, d.o.o., Sarajevo
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779350/ https://www.ncbi.nlm.nih.gov/pubmed/26980931 http://dx.doi.org/10.5455/medarh.2016.70.44-47 |
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author | Dacaj, Ramadan Izetbegovic, Sebija Stojkanovic, Goran Dreshaj, Skender |
author_facet | Dacaj, Ramadan Izetbegovic, Sebija Stojkanovic, Goran Dreshaj, Skender |
author_sort | Dacaj, Ramadan |
collection | PubMed |
description | AIM: The aim of this study was to evaluate biochemical parameters in serum of women with preeclampsia and IUGR. MATERIAL AND METHODS: A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following values of biochemical parameters in serum of mother and fetuses: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), bilirubin (indirect and direct) and cholesterol. A blood for analysis was drawn from the cubital vein of mothers and the umbilical vein of the fetuses during delivery period. RESULTS: The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p > 0.05. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. There was a significant statistically difference in serum value of AST, ALT, LDH and total cholesterol between women with preeclampsia and IUGR and healthy pregnant women (all p < 0.001). CONCLUSION: Measurement of AST, ALT, LDH, and total cholesterol in serum of pregnant women and newborns with IUGR allows the differentiation and threatening risk of perinatal complications due to hypoxia. |
format | Online Article Text |
id | pubmed-4779350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | AVICENA, d.o.o., Sarajevo |
record_format | MEDLINE/PubMed |
spelling | pubmed-47793502016-03-15 Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction Dacaj, Ramadan Izetbegovic, Sebija Stojkanovic, Goran Dreshaj, Skender Med Arch Original Paper AIM: The aim of this study was to evaluate biochemical parameters in serum of women with preeclampsia and IUGR. MATERIAL AND METHODS: A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following values of biochemical parameters in serum of mother and fetuses: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), bilirubin (indirect and direct) and cholesterol. A blood for analysis was drawn from the cubital vein of mothers and the umbilical vein of the fetuses during delivery period. RESULTS: The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p > 0.05. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. There was a significant statistically difference in serum value of AST, ALT, LDH and total cholesterol between women with preeclampsia and IUGR and healthy pregnant women (all p < 0.001). CONCLUSION: Measurement of AST, ALT, LDH, and total cholesterol in serum of pregnant women and newborns with IUGR allows the differentiation and threatening risk of perinatal complications due to hypoxia. AVICENA, d.o.o., Sarajevo 2016-02 2016-01-31 /pmc/articles/PMC4779350/ /pubmed/26980931 http://dx.doi.org/10.5455/medarh.2016.70.44-47 Text en Copyright: © Ramadan Dacaj, Sebija Izetbegovic, Goran Stojkanovic, Skender Dresha http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Paper Dacaj, Ramadan Izetbegovic, Sebija Stojkanovic, Goran Dreshaj, Skender Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction |
title | Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction |
title_full | Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction |
title_fullStr | Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction |
title_full_unstemmed | Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction |
title_short | Elevated Liver Enzymes in Cases of Preeclampsia and Intrauterine Growth Restriction |
title_sort | elevated liver enzymes in cases of preeclampsia and intrauterine growth restriction |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779350/ https://www.ncbi.nlm.nih.gov/pubmed/26980931 http://dx.doi.org/10.5455/medarh.2016.70.44-47 |
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