Restriction of HIV-1-based lentiviral vectors in adult primary marrow-derived and peripheral mobilized human CD34+ hematopoietic stem and progenitor cells occurs prior to viral DNA integration

BACKGROUND: Gene therapy is currently being attempted using a number of delivery vehicles including lentiviral-based vectors. The delivery and insertion of a gene using lentiviral-based vectors involves multiple discrete steps, including reverse transcription of viral RNA into DNA, nuclear entry, in...

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Detalles Bibliográficos
Autores principales: Griffin, Daniel O., Goff, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779582/
https://www.ncbi.nlm.nih.gov/pubmed/26945863
http://dx.doi.org/10.1186/s12977-016-0246-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779582/
https://www.ncbi.nlm.nih.gov/pubmed/26945863
http://dx.doi.org/10.1186/s12977-016-0246-0

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