Cargando…

Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study

BACKGROUND: The distribution of adipose tissue has been evaluated in relation to cardiovascular risk factors and biochemical components of the metabolic syndrome. Neck circumference (NC) has been shown to have a strong relationship with cardiovascular disease (CVD) and may be a novel indicator of CV...

Descripción completa

Detalles Bibliográficos
Autores principales: Dai, Yingnan, Wan, Xiaojing, Li, Xin, Jin, Enze, Li, Xueqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779588/
https://www.ncbi.nlm.nih.gov/pubmed/26946432
http://dx.doi.org/10.1186/s12944-016-0218-3
_version_ 1782419645669572608
author Dai, Yingnan
Wan, Xiaojing
Li, Xin
Jin, Enze
Li, Xueqi
author_facet Dai, Yingnan
Wan, Xiaojing
Li, Xin
Jin, Enze
Li, Xueqi
author_sort Dai, Yingnan
collection PubMed
description BACKGROUND: The distribution of adipose tissue has been evaluated in relation to cardiovascular risk factors and biochemical components of the metabolic syndrome. Neck circumference (NC) has been shown to have a strong relationship with cardiovascular disease (CVD) and may be a novel indicator of CVD. The aim of this study was to compare the incidence of CVD events in cohorts with different NC distributions, and to correlate NC with future CVD events and relative mortality. METHODS: A prospective cohort study was performed on 12,151 high-risk cardiology outpatients from 2004 until 2014. Anthropometric parameters like body mass index, NC, waist circumference, and hip circumference were measured at baseline and follow-up and compared in different cohorts with high, medium, and low NC. Fatal and non-fatal CVD events were compared in the follow-up study, and survival analysis was conducted. Independent Chi-square tests were performed to compare the incidence of CVD events and mortality among the cohorts and analyze the interactions. RESULTS: The subjects comprised of 6696 women and 5819 men who completed a mean 8.8-year follow-up. All of the participants had two or more CVD risk factors at baseline. At the end of the study, 4049 CVD events had occurred in 2304 participants. The incidence of non-fatal CVD events was 14.08, 16,65, and 25.21 % in the low-NC, medium-NC, and high-NC cohorts, respectively (p < 0.001). The all-cause mortality was 9.77, 11.93, and 19.31 %, and CVD mortality, 4.00, 6.29, and 8.01 %, respectively (p < 0.001). Compared with baseline, the number of CVD risk factors in participants had increased from 2.6, 3.0, and 3.4 to 3.5, 4.1, and 4.7 in the low-, medium-, and high-NC cohorts (34, 36, and 38 %), respectively. The event-free survival rate was 95.32, 80.15, and 75.47 %, respectively. CONCLUSIONS: A higher NC indicated a higher incidence of future fatal and non-fatal CVD events and all-cause mortality in both male and female high-risk participants. CVD risk factors increased more in the higher NC group. NC as a novel indicator of CVD showed good predictive ability for CVD events and mortality in a high-risk population.
format Online
Article
Text
id pubmed-4779588
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-47795882016-03-07 Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study Dai, Yingnan Wan, Xiaojing Li, Xin Jin, Enze Li, Xueqi Lipids Health Dis Research BACKGROUND: The distribution of adipose tissue has been evaluated in relation to cardiovascular risk factors and biochemical components of the metabolic syndrome. Neck circumference (NC) has been shown to have a strong relationship with cardiovascular disease (CVD) and may be a novel indicator of CVD. The aim of this study was to compare the incidence of CVD events in cohorts with different NC distributions, and to correlate NC with future CVD events and relative mortality. METHODS: A prospective cohort study was performed on 12,151 high-risk cardiology outpatients from 2004 until 2014. Anthropometric parameters like body mass index, NC, waist circumference, and hip circumference were measured at baseline and follow-up and compared in different cohorts with high, medium, and low NC. Fatal and non-fatal CVD events were compared in the follow-up study, and survival analysis was conducted. Independent Chi-square tests were performed to compare the incidence of CVD events and mortality among the cohorts and analyze the interactions. RESULTS: The subjects comprised of 6696 women and 5819 men who completed a mean 8.8-year follow-up. All of the participants had two or more CVD risk factors at baseline. At the end of the study, 4049 CVD events had occurred in 2304 participants. The incidence of non-fatal CVD events was 14.08, 16,65, and 25.21 % in the low-NC, medium-NC, and high-NC cohorts, respectively (p < 0.001). The all-cause mortality was 9.77, 11.93, and 19.31 %, and CVD mortality, 4.00, 6.29, and 8.01 %, respectively (p < 0.001). Compared with baseline, the number of CVD risk factors in participants had increased from 2.6, 3.0, and 3.4 to 3.5, 4.1, and 4.7 in the low-, medium-, and high-NC cohorts (34, 36, and 38 %), respectively. The event-free survival rate was 95.32, 80.15, and 75.47 %, respectively. CONCLUSIONS: A higher NC indicated a higher incidence of future fatal and non-fatal CVD events and all-cause mortality in both male and female high-risk participants. CVD risk factors increased more in the higher NC group. NC as a novel indicator of CVD showed good predictive ability for CVD events and mortality in a high-risk population. BioMed Central 2016-03-05 /pmc/articles/PMC4779588/ /pubmed/26946432 http://dx.doi.org/10.1186/s12944-016-0218-3 Text en © Dai et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Dai, Yingnan
Wan, Xiaojing
Li, Xin
Jin, Enze
Li, Xueqi
Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study
title Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study
title_full Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study
title_fullStr Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study
title_full_unstemmed Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study
title_short Neck circumference and future cardiovascular events in a high-risk population—A prospective cohort study
title_sort neck circumference and future cardiovascular events in a high-risk population—a prospective cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779588/
https://www.ncbi.nlm.nih.gov/pubmed/26946432
http://dx.doi.org/10.1186/s12944-016-0218-3
work_keys_str_mv AT daiyingnan neckcircumferenceandfuturecardiovasculareventsinahighriskpopulationaprospectivecohortstudy
AT wanxiaojing neckcircumferenceandfuturecardiovasculareventsinahighriskpopulationaprospectivecohortstudy
AT lixin neckcircumferenceandfuturecardiovasculareventsinahighriskpopulationaprospectivecohortstudy
AT jinenze neckcircumferenceandfuturecardiovasculareventsinahighriskpopulationaprospectivecohortstudy
AT lixueqi neckcircumferenceandfuturecardiovasculareventsinahighriskpopulationaprospectivecohortstudy