Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia

Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combina...

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Autores principales: Adler, David H., Wallace, Melissa, Bennie, Thola, Abar, Beau, Meiring, Tracy L., Williamson, Anna-Lise, Bekker, Linda-Gail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779813/
https://www.ncbi.nlm.nih.gov/pubmed/26997954
http://dx.doi.org/10.1155/2016/7310894
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author Adler, David H.
Wallace, Melissa
Bennie, Thola
Abar, Beau
Meiring, Tracy L.
Williamson, Anna-Lise
Bekker, Linda-Gail
author_facet Adler, David H.
Wallace, Melissa
Bennie, Thola
Abar, Beau
Meiring, Tracy L.
Williamson, Anna-Lise
Bekker, Linda-Gail
author_sort Adler, David H.
collection PubMed
description Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combination of HIV coinfection and presence of multiple concurrent HPV infections on the risk of cervical dysplasia is uncertain. We compared the results of HPV testing and Pap smears between HIV-infected and HIV-uninfected young women to assess the cumulative impact of these two conditions. We found that both HIV and the presence of multiple concurrent HPV infections are associated with increased risk of associated Pap smear abnormality and that the impact of these two risk factors may be additive.
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spelling pubmed-47798132016-03-20 Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia Adler, David H. Wallace, Melissa Bennie, Thola Abar, Beau Meiring, Tracy L. Williamson, Anna-Lise Bekker, Linda-Gail Adv Virol Research Article Infection with HIV is known to increase the risk of cervical cancer. In addition, evidence suggests that concurrent infection with multiple human papillomavirus (HPV) genotypes increases the risk of cervical dysplasia more than infection with a single HPV genotype. However, the impact of the combination of HIV coinfection and presence of multiple concurrent HPV infections on the risk of cervical dysplasia is uncertain. We compared the results of HPV testing and Pap smears between HIV-infected and HIV-uninfected young women to assess the cumulative impact of these two conditions. We found that both HIV and the presence of multiple concurrent HPV infections are associated with increased risk of associated Pap smear abnormality and that the impact of these two risk factors may be additive. Hindawi Publishing Corporation 2016 2016-02-22 /pmc/articles/PMC4779813/ /pubmed/26997954 http://dx.doi.org/10.1155/2016/7310894 Text en Copyright © 2016 David H. Adler et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Adler, David H.
Wallace, Melissa
Bennie, Thola
Abar, Beau
Meiring, Tracy L.
Williamson, Anna-Lise
Bekker, Linda-Gail
Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
title Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
title_full Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
title_fullStr Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
title_full_unstemmed Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
title_short Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia
title_sort cumulative impact of hiv and multiple concurrent human papillomavirus infections on the risk of cervical dysplasia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779813/
https://www.ncbi.nlm.nih.gov/pubmed/26997954
http://dx.doi.org/10.1155/2016/7310894
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