Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate

AKR1B10 is involved in hepatocarcinogenesis via modulation of fatty acid and lipid synthesis. AKR1B10 inhibition results in apoptosis of tumor cells whose lipids, especially phospholipids, were decreased by over 50%, suggesting involvement of phospholipids like sphingosine-1-phosphate (S1P) in AKR1B...

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Detalles Bibliográficos
Autores principales: Jin, Junfei, Liao, Weijia, Yao, Wenmin, Zhu, Rongping, Li, Yulan, He, Songqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780005/
https://www.ncbi.nlm.nih.gov/pubmed/26948042
http://dx.doi.org/10.1038/srep22746

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