Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods

BACKGROUND: Home fortification using sachets of micronutrient powder (e.g. “Sprinkles”) is a food-based approach offering an alternative to high dose vitamin A (VA) supplements for infants. The primary objective was to investigate the impact of VA-home fortification on infant VA pool size. The secon...

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Autores principales: Newton, Sam, Owusu-Agyei, Seth, Asante, Kwaku Poku, Amoaful, Esi, Mahama, Emmanuel, Tchum, Samuel Kofi, Ali, Martha, Adjei, Kwame, Davis, Christopher R., Tanumihardjo, Sherry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780150/
https://www.ncbi.nlm.nih.gov/pubmed/26955479
http://dx.doi.org/10.1186/s13690-016-0121-4
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author Newton, Sam
Owusu-Agyei, Seth
Asante, Kwaku Poku
Amoaful, Esi
Mahama, Emmanuel
Tchum, Samuel Kofi
Ali, Martha
Adjei, Kwame
Davis, Christopher R.
Tanumihardjo, Sherry A.
author_facet Newton, Sam
Owusu-Agyei, Seth
Asante, Kwaku Poku
Amoaful, Esi
Mahama, Emmanuel
Tchum, Samuel Kofi
Ali, Martha
Adjei, Kwame
Davis, Christopher R.
Tanumihardjo, Sherry A.
author_sort Newton, Sam
collection PubMed
description BACKGROUND: Home fortification using sachets of micronutrient powder (e.g. “Sprinkles”) is a food-based approach offering an alternative to high dose vitamin A (VA) supplements for infants. The primary objective was to investigate the impact of VA-home fortification on infant VA pool size. The secondary objective was to compare VA status of infants assessed by the modified relative dose response (MRDR) test before and the (13)C-retinol isotope dilution ((13)C-RID) test in the same infants after vitamin A supplementation. METHODS: A randomized-controlled trial was conducted in 7–9 month old infants in Ghana. Eligible children were randomly allocated to receive a daily sachet of “Sprinkles” with or without VA for 5 months added to complementary foods. The MRDR test indirectly determined VA liver reserves at baseline and the (13)C-RID determined VA body pool at follow-up in the same cohort of children. RESULTS: At baseline, the MRDR values (95 % CI) for infants were comparable in the intervention and control groups: normal at 0·032 (SD 0·018) (0·025–0·038) and 0·031 (SD 0·018) (0·024–0·038), respectively. After intervention, total body stores (TBS) and liver retinol concentrations did not differ between intervention and control groups; TBS were 436 (SD 303) and 434 (SD 186) μmol, respectively, and estimated liver concentrations were 0·82 (SD 0·53) and 0·79 (SD 0·36) μmol/g liver, indicating adequate reserves in all children. CONCLUSIONS: Both the MRDR and (3)C-RID tests confirmed that the infants had adequate VA status before and after home fortification of their complementary foods. These tests offered more information than serum retinol concentrations alone, which predicted VA deficiency using current suggested cutoffs not corrected for inflammation status.
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spelling pubmed-47801502016-03-08 Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods Newton, Sam Owusu-Agyei, Seth Asante, Kwaku Poku Amoaful, Esi Mahama, Emmanuel Tchum, Samuel Kofi Ali, Martha Adjei, Kwame Davis, Christopher R. Tanumihardjo, Sherry A. Arch Public Health Research BACKGROUND: Home fortification using sachets of micronutrient powder (e.g. “Sprinkles”) is a food-based approach offering an alternative to high dose vitamin A (VA) supplements for infants. The primary objective was to investigate the impact of VA-home fortification on infant VA pool size. The secondary objective was to compare VA status of infants assessed by the modified relative dose response (MRDR) test before and the (13)C-retinol isotope dilution ((13)C-RID) test in the same infants after vitamin A supplementation. METHODS: A randomized-controlled trial was conducted in 7–9 month old infants in Ghana. Eligible children were randomly allocated to receive a daily sachet of “Sprinkles” with or without VA for 5 months added to complementary foods. The MRDR test indirectly determined VA liver reserves at baseline and the (13)C-RID determined VA body pool at follow-up in the same cohort of children. RESULTS: At baseline, the MRDR values (95 % CI) for infants were comparable in the intervention and control groups: normal at 0·032 (SD 0·018) (0·025–0·038) and 0·031 (SD 0·018) (0·024–0·038), respectively. After intervention, total body stores (TBS) and liver retinol concentrations did not differ between intervention and control groups; TBS were 436 (SD 303) and 434 (SD 186) μmol, respectively, and estimated liver concentrations were 0·82 (SD 0·53) and 0·79 (SD 0·36) μmol/g liver, indicating adequate reserves in all children. CONCLUSIONS: Both the MRDR and (3)C-RID tests confirmed that the infants had adequate VA status before and after home fortification of their complementary foods. These tests offered more information than serum retinol concentrations alone, which predicted VA deficiency using current suggested cutoffs not corrected for inflammation status. BioMed Central 2016-03-07 /pmc/articles/PMC4780150/ /pubmed/26955479 http://dx.doi.org/10.1186/s13690-016-0121-4 Text en © Newton et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Newton, Sam
Owusu-Agyei, Seth
Asante, Kwaku Poku
Amoaful, Esi
Mahama, Emmanuel
Tchum, Samuel Kofi
Ali, Martha
Adjei, Kwame
Davis, Christopher R.
Tanumihardjo, Sherry A.
Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods
title Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods
title_full Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods
title_fullStr Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods
title_full_unstemmed Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods
title_short Vitamin A status and body pool size of infants before and after consuming fortified home-based complementary foods
title_sort vitamin a status and body pool size of infants before and after consuming fortified home-based complementary foods
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780150/
https://www.ncbi.nlm.nih.gov/pubmed/26955479
http://dx.doi.org/10.1186/s13690-016-0121-4
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