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Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Physiologically based pharmacokinetic (PBPK) modeling can provide an effective way to utilize in vitro and in silico based information in modern risk assessment for children and other potentially sensitive populations. In this review, we describe the process of in vitro to in vivo extrapolation (IVI...

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Detalles Bibliográficos
Autores principales:	Yoon, Miyoung, Clewell, Harvey J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society of Toxicology 2016
Materias:	Special Issue Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780231/ https://www.ncbi.nlm.nih.gov/pubmed/26977255 http://dx.doi.org/10.5487/TR.2016.32.1.015

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