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Advances in the Development and Validation of Test Methods in the United States
The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) provides validation support for US Federal agencies and the US Tox21 interagency consortium, an interagency collaboration that is using high throughput screening (HTS) and other advan...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society of Toxicology
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780239/ https://www.ncbi.nlm.nih.gov/pubmed/26977254 http://dx.doi.org/10.5487/TR.2016.32.1.009 |
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author | Casey, Warren M. |
author_facet | Casey, Warren M. |
author_sort | Casey, Warren M. |
collection | PubMed |
description | The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) provides validation support for US Federal agencies and the US Tox21 interagency consortium, an interagency collaboration that is using high throughput screening (HTS) and other advanced approaches to better understand and predict chemical hazards to humans and the environment. The use of HTS data from assays relevant to the estrogen receptor signaling data pathway is used as an example of how HTS data can be combined with computational modeling to meet the needs of US agencies. As brief summary of US efforts in the areas of biologics testing, acute toxicity, and skin sensitization will also be provided. |
format | Online Article Text |
id | pubmed-4780239 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Society of Toxicology |
record_format | MEDLINE/PubMed |
spelling | pubmed-47802392016-03-14 Advances in the Development and Validation of Test Methods in the United States Casey, Warren M. Toxicol Res Special Issue Article The National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) provides validation support for US Federal agencies and the US Tox21 interagency consortium, an interagency collaboration that is using high throughput screening (HTS) and other advanced approaches to better understand and predict chemical hazards to humans and the environment. The use of HTS data from assays relevant to the estrogen receptor signaling data pathway is used as an example of how HTS data can be combined with computational modeling to meet the needs of US agencies. As brief summary of US efforts in the areas of biologics testing, acute toxicity, and skin sensitization will also be provided. Korean Society of Toxicology 2016-01 2016-01-31 /pmc/articles/PMC4780239/ /pubmed/26977254 http://dx.doi.org/10.5487/TR.2016.32.1.009 Text en Copyright © 2016, The Korean Society Of Toxicology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Issue Article Casey, Warren M. Advances in the Development and Validation of Test Methods in the United States |
title | Advances in the Development and Validation of Test Methods in the United States |
title_full | Advances in the Development and Validation of Test Methods in the United States |
title_fullStr | Advances in the Development and Validation of Test Methods in the United States |
title_full_unstemmed | Advances in the Development and Validation of Test Methods in the United States |
title_short | Advances in the Development and Validation of Test Methods in the United States |
title_sort | advances in the development and validation of test methods in the united states |
topic | Special Issue Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780239/ https://www.ncbi.nlm.nih.gov/pubmed/26977254 http://dx.doi.org/10.5487/TR.2016.32.1.009 |
work_keys_str_mv | AT caseywarrenm advancesinthedevelopmentandvalidationoftestmethodsintheunitedstates |