Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1

T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. We therefore correlated the extent of immune infiltration into colorectal tumo...

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Detalles Bibliográficos
Autores principales: Dunne, Margaret R., Ryan, Ciara, Nolan, Bláthnaid, Tosetto, Miriam, Geraghty, Robert, Winter, Des C., O’Connell, P. Ronan, Hyland, John M., Doherty, Glen A., Sheahan, Kieran, Ryan, Elizabeth J., Fletcher, Jean M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780371/
https://www.ncbi.nlm.nih.gov/pubmed/27014625
http://dx.doi.org/10.3389/fonc.2016.00050

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