Use of string test and stool specimens to diagnose pulmonary tuberculosis()

BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10–85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum. METHODS: The feasibility of using MTB/RIF and culture on stool and stri...

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Detalles Bibliográficos
Autores principales: DiNardo, Andrew R., Hahn, Andrew, Leyden, Jacinta, Stager, Charles, Jo Baron, Ellen, Graviss, Edward A., Mandalakas, Anna M., Guy, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780405/
https://www.ncbi.nlm.nih.gov/pubmed/26523638
http://dx.doi.org/10.1016/j.ijid.2015.10.022
Descripción
Sumario:BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10–85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum. METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied. RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB. CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.

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