Use of string test and stool specimens to diagnose pulmonary tuberculosis()

BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10–85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum. METHODS: The feasibility of using MTB/RIF and culture on stool and stri...

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Autores principales: DiNardo, Andrew R., Hahn, Andrew, Leyden, Jacinta, Stager, Charles, Jo Baron, Ellen, Graviss, Edward A., Mandalakas, Anna M., Guy, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780405/
https://www.ncbi.nlm.nih.gov/pubmed/26523638
http://dx.doi.org/10.1016/j.ijid.2015.10.022
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author DiNardo, Andrew R.
Hahn, Andrew
Leyden, Jacinta
Stager, Charles
Jo Baron, Ellen
Graviss, Edward A.
Mandalakas, Anna M.
Guy, Elizabeth
author_facet DiNardo, Andrew R.
Hahn, Andrew
Leyden, Jacinta
Stager, Charles
Jo Baron, Ellen
Graviss, Edward A.
Mandalakas, Anna M.
Guy, Elizabeth
author_sort DiNardo, Andrew R.
collection PubMed
description BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10–85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum. METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied. RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB. CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation.
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spelling pubmed-47804052016-03-07 Use of string test and stool specimens to diagnose pulmonary tuberculosis() DiNardo, Andrew R. Hahn, Andrew Leyden, Jacinta Stager, Charles Jo Baron, Ellen Graviss, Edward A. Mandalakas, Anna M. Guy, Elizabeth Int J Infect Dis Article BACKGROUND: The Xpert MTB/RIF (MTB/RIF) test has advanced the field of tuberculosis (TB) diagnostics; however, depending on age and HIV status, 10–85% of individuals with presumed pulmonary TB (PTB) are unable to produce sputum. METHODS: The feasibility of using MTB/RIF and culture on stool and string test specimens from 13 adult patients with presumed PTB was studied. RESULTS: The string test was well tolerated with a median Wong Baker Faces score of 2. The string test had 100% sensitivity and specificity by MTB/RIF and 87.5% sensitivity and 100% specificity by culture. In stool, Mycobacterium tuberculosis DNA was detected in all cases of culture-confirmed PTB. CONCLUSION: The string test and stool provide diagnostic specimens that warrant further investigation. 2015-10-30 2015-12 /pmc/articles/PMC4780405/ /pubmed/26523638 http://dx.doi.org/10.1016/j.ijid.2015.10.022 Text en This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
DiNardo, Andrew R.
Hahn, Andrew
Leyden, Jacinta
Stager, Charles
Jo Baron, Ellen
Graviss, Edward A.
Mandalakas, Anna M.
Guy, Elizabeth
Use of string test and stool specimens to diagnose pulmonary tuberculosis()
title Use of string test and stool specimens to diagnose pulmonary tuberculosis()
title_full Use of string test and stool specimens to diagnose pulmonary tuberculosis()
title_fullStr Use of string test and stool specimens to diagnose pulmonary tuberculosis()
title_full_unstemmed Use of string test and stool specimens to diagnose pulmonary tuberculosis()
title_short Use of string test and stool specimens to diagnose pulmonary tuberculosis()
title_sort use of string test and stool specimens to diagnose pulmonary tuberculosis()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780405/
https://www.ncbi.nlm.nih.gov/pubmed/26523638
http://dx.doi.org/10.1016/j.ijid.2015.10.022
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