Cargando…
Fecal Calprotectin in Healthy Children Aged 1-4 Years
OBJECTIVE: Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. METHODS: Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure the...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780696/ https://www.ncbi.nlm.nih.gov/pubmed/26950440 http://dx.doi.org/10.1371/journal.pone.0150725 |
_version_ | 1782419789341261824 |
---|---|
author | Zhu, Qingling Li, Feng Wang, Junli Shen, Lixiao Sheng, Xiaoyang |
author_facet | Zhu, Qingling Li, Feng Wang, Junli Shen, Lixiao Sheng, Xiaoyang |
author_sort | Zhu, Qingling |
collection | PubMed |
description | OBJECTIVE: Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. METHODS: Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure these children meet the inclusion criteria, and some clinical and sociodemographic factors were collected. Anthro software (version 3.1) was used to calculated Length-for-age Z-scores (LAZ), weight-for-age Z-scores (WAZ), and weight-for-length Z-scores (WLZ) respectively. Fecal calprotectin was detected by a commercially available ELISA. RESULTS: In total 274 children were recruited, with age ranging from 1 to 4 years old. The median FC concentration was 83.19 μg/g [range 4.58 to 702.50 μg/g, interquartile range (IQR) 14.69–419.45 μg/g] or 1.92 log10 μg/g (range 0.66 log10 to 2.85 log10 μg/g, IQR 1.17 log10-2.62 log10 μg/g). All of the children were divided into three groups, 1–2 years (12–24 months), 2–3 years (24–36 months), 3–4 years (36–48 months), with median FC concentrations 96.14 μg/g (1.98 log10 μg/g), 81.48 μg/g (1.91 log10 μg/g), 65.36 μg/g (1.82 log10 μg/g), respectively. There was similar FC level between boys and girls. FC concentrations showed a downward trend by the growing age groups. A statistic difference was found in FC concentrations among groups 1–2 years, 2–3 years and 3–4 years (P = 0.016). In inter-groups comparison, a significant difference was found between children aged 1–2 years and children aged 3–4 years (P = 0.007). A negative correlation trend was found between age and FC concentration (Spearman's rho = -0.167, P = 0.005) in all the participants. A simple correlation was performed among WLZ, WAZ, birth weight, or birth length with FC, and there was no correlation being observed. CONCLUSION: Children aged from 1 to 4 years old have lower FC concentrations compared with healthy infants (<1years), and higher FC concentrations when comparing with children older than 4 years and adults. |
format | Online Article Text |
id | pubmed-4780696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47806962016-03-23 Fecal Calprotectin in Healthy Children Aged 1-4 Years Zhu, Qingling Li, Feng Wang, Junli Shen, Lixiao Sheng, Xiaoyang PLoS One Research Article OBJECTIVE: Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. METHODS: Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure these children meet the inclusion criteria, and some clinical and sociodemographic factors were collected. Anthro software (version 3.1) was used to calculated Length-for-age Z-scores (LAZ), weight-for-age Z-scores (WAZ), and weight-for-length Z-scores (WLZ) respectively. Fecal calprotectin was detected by a commercially available ELISA. RESULTS: In total 274 children were recruited, with age ranging from 1 to 4 years old. The median FC concentration was 83.19 μg/g [range 4.58 to 702.50 μg/g, interquartile range (IQR) 14.69–419.45 μg/g] or 1.92 log10 μg/g (range 0.66 log10 to 2.85 log10 μg/g, IQR 1.17 log10-2.62 log10 μg/g). All of the children were divided into three groups, 1–2 years (12–24 months), 2–3 years (24–36 months), 3–4 years (36–48 months), with median FC concentrations 96.14 μg/g (1.98 log10 μg/g), 81.48 μg/g (1.91 log10 μg/g), 65.36 μg/g (1.82 log10 μg/g), respectively. There was similar FC level between boys and girls. FC concentrations showed a downward trend by the growing age groups. A statistic difference was found in FC concentrations among groups 1–2 years, 2–3 years and 3–4 years (P = 0.016). In inter-groups comparison, a significant difference was found between children aged 1–2 years and children aged 3–4 years (P = 0.007). A negative correlation trend was found between age and FC concentration (Spearman's rho = -0.167, P = 0.005) in all the participants. A simple correlation was performed among WLZ, WAZ, birth weight, or birth length with FC, and there was no correlation being observed. CONCLUSION: Children aged from 1 to 4 years old have lower FC concentrations compared with healthy infants (<1years), and higher FC concentrations when comparing with children older than 4 years and adults. Public Library of Science 2016-03-07 /pmc/articles/PMC4780696/ /pubmed/26950440 http://dx.doi.org/10.1371/journal.pone.0150725 Text en © 2016 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhu, Qingling Li, Feng Wang, Junli Shen, Lixiao Sheng, Xiaoyang Fecal Calprotectin in Healthy Children Aged 1-4 Years |
title | Fecal Calprotectin in Healthy Children Aged 1-4 Years |
title_full | Fecal Calprotectin in Healthy Children Aged 1-4 Years |
title_fullStr | Fecal Calprotectin in Healthy Children Aged 1-4 Years |
title_full_unstemmed | Fecal Calprotectin in Healthy Children Aged 1-4 Years |
title_short | Fecal Calprotectin in Healthy Children Aged 1-4 Years |
title_sort | fecal calprotectin in healthy children aged 1-4 years |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780696/ https://www.ncbi.nlm.nih.gov/pubmed/26950440 http://dx.doi.org/10.1371/journal.pone.0150725 |
work_keys_str_mv | AT zhuqingling fecalcalprotectininhealthychildrenaged14years AT lifeng fecalcalprotectininhealthychildrenaged14years AT wangjunli fecalcalprotectininhealthychildrenaged14years AT shenlixiao fecalcalprotectininhealthychildrenaged14years AT shengxiaoyang fecalcalprotectininhealthychildrenaged14years |