Cargando…

Fecal Calprotectin in Healthy Children Aged 1-4 Years

OBJECTIVE: Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. METHODS: Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Qingling, Li, Feng, Wang, Junli, Shen, Lixiao, Sheng, Xiaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780696/
https://www.ncbi.nlm.nih.gov/pubmed/26950440
http://dx.doi.org/10.1371/journal.pone.0150725
_version_ 1782419789341261824
author Zhu, Qingling
Li, Feng
Wang, Junli
Shen, Lixiao
Sheng, Xiaoyang
author_facet Zhu, Qingling
Li, Feng
Wang, Junli
Shen, Lixiao
Sheng, Xiaoyang
author_sort Zhu, Qingling
collection PubMed
description OBJECTIVE: Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. METHODS: Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure these children meet the inclusion criteria, and some clinical and sociodemographic factors were collected. Anthro software (version 3.1) was used to calculated Length-for-age Z-scores (LAZ), weight-for-age Z-scores (WAZ), and weight-for-length Z-scores (WLZ) respectively. Fecal calprotectin was detected by a commercially available ELISA. RESULTS: In total 274 children were recruited, with age ranging from 1 to 4 years old. The median FC concentration was 83.19 μg/g [range 4.58 to 702.50 μg/g, interquartile range (IQR) 14.69–419.45 μg/g] or 1.92 log10 μg/g (range 0.66 log10 to 2.85 log10 μg/g, IQR 1.17 log10-2.62 log10 μg/g). All of the children were divided into three groups, 1–2 years (12–24 months), 2–3 years (24–36 months), 3–4 years (36–48 months), with median FC concentrations 96.14 μg/g (1.98 log10 μg/g), 81.48 μg/g (1.91 log10 μg/g), 65.36 μg/g (1.82 log10 μg/g), respectively. There was similar FC level between boys and girls. FC concentrations showed a downward trend by the growing age groups. A statistic difference was found in FC concentrations among groups 1–2 years, 2–3 years and 3–4 years (P = 0.016). In inter-groups comparison, a significant difference was found between children aged 1–2 years and children aged 3–4 years (P = 0.007). A negative correlation trend was found between age and FC concentration (Spearman's rho = -0.167, P = 0.005) in all the participants. A simple correlation was performed among WLZ, WAZ, birth weight, or birth length with FC, and there was no correlation being observed. CONCLUSION: Children aged from 1 to 4 years old have lower FC concentrations compared with healthy infants (<1years), and higher FC concentrations when comparing with children older than 4 years and adults.
format Online
Article
Text
id pubmed-4780696
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-47806962016-03-23 Fecal Calprotectin in Healthy Children Aged 1-4 Years Zhu, Qingling Li, Feng Wang, Junli Shen, Lixiao Sheng, Xiaoyang PLoS One Research Article OBJECTIVE: Calprotectin has been well emulated recently in adults as well as in children. The aim of this study was to assess fecal calprotectin concentrations in healthy children aged from 1 to 4 years. METHODS: Volunteers were enlisted from 3 nurseries. A brief questionnaire was used to ensure these children meet the inclusion criteria, and some clinical and sociodemographic factors were collected. Anthro software (version 3.1) was used to calculated Length-for-age Z-scores (LAZ), weight-for-age Z-scores (WAZ), and weight-for-length Z-scores (WLZ) respectively. Fecal calprotectin was detected by a commercially available ELISA. RESULTS: In total 274 children were recruited, with age ranging from 1 to 4 years old. The median FC concentration was 83.19 μg/g [range 4.58 to 702.50 μg/g, interquartile range (IQR) 14.69–419.45 μg/g] or 1.92 log10 μg/g (range 0.66 log10 to 2.85 log10 μg/g, IQR 1.17 log10-2.62 log10 μg/g). All of the children were divided into three groups, 1–2 years (12–24 months), 2–3 years (24–36 months), 3–4 years (36–48 months), with median FC concentrations 96.14 μg/g (1.98 log10 μg/g), 81.48 μg/g (1.91 log10 μg/g), 65.36 μg/g (1.82 log10 μg/g), respectively. There was similar FC level between boys and girls. FC concentrations showed a downward trend by the growing age groups. A statistic difference was found in FC concentrations among groups 1–2 years, 2–3 years and 3–4 years (P = 0.016). In inter-groups comparison, a significant difference was found between children aged 1–2 years and children aged 3–4 years (P = 0.007). A negative correlation trend was found between age and FC concentration (Spearman's rho = -0.167, P = 0.005) in all the participants. A simple correlation was performed among WLZ, WAZ, birth weight, or birth length with FC, and there was no correlation being observed. CONCLUSION: Children aged from 1 to 4 years old have lower FC concentrations compared with healthy infants (<1years), and higher FC concentrations when comparing with children older than 4 years and adults. Public Library of Science 2016-03-07 /pmc/articles/PMC4780696/ /pubmed/26950440 http://dx.doi.org/10.1371/journal.pone.0150725 Text en © 2016 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhu, Qingling
Li, Feng
Wang, Junli
Shen, Lixiao
Sheng, Xiaoyang
Fecal Calprotectin in Healthy Children Aged 1-4 Years
title Fecal Calprotectin in Healthy Children Aged 1-4 Years
title_full Fecal Calprotectin in Healthy Children Aged 1-4 Years
title_fullStr Fecal Calprotectin in Healthy Children Aged 1-4 Years
title_full_unstemmed Fecal Calprotectin in Healthy Children Aged 1-4 Years
title_short Fecal Calprotectin in Healthy Children Aged 1-4 Years
title_sort fecal calprotectin in healthy children aged 1-4 years
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780696/
https://www.ncbi.nlm.nih.gov/pubmed/26950440
http://dx.doi.org/10.1371/journal.pone.0150725
work_keys_str_mv AT zhuqingling fecalcalprotectininhealthychildrenaged14years
AT lifeng fecalcalprotectininhealthychildrenaged14years
AT wangjunli fecalcalprotectininhealthychildrenaged14years
AT shenlixiao fecalcalprotectininhealthychildrenaged14years
AT shengxiaoyang fecalcalprotectininhealthychildrenaged14years