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microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration

The aggregation of Aβ42-peptides and the formation of drusen in age-related macular degeneration (AMD) are due in part to the inability of homeostatic phagocytic mechanisms to clear self-aggregating Aβ42-peptides from the extracellular space. The triggering receptor expressed in myeloid/microglial c...

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Detalles Bibliográficos
Autores principales:	Bhattacharjee, Surjyadipta, Zhao, Yuhai, Dua, Prerna, Rogaev, Evgeny I., Lukiw, Walter J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780721/ https://www.ncbi.nlm.nih.gov/pubmed/26949937 http://dx.doi.org/10.1371/journal.pone.0150211

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