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Protective LRRK2 R1398H Variant Enhances GTPase and Wnt Signaling Activity

Mutations in LRRK2 are a common cause of familial and idiopathic Parkinson’s disease (PD). Recently, the LRRK2 GTPase domain R1398H variant was suggested in genetic studies to confer protection against PD but mechanistic data supporting this is lacking. Here, we present evidence that R1398H affects...

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Detalles Bibliográficos
Autores principales: Nixon-Abell, Jonathon, Berwick, Daniel C., Grannó, Simone, Spain, Victoria A., Blackstone, Craig, Harvey, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781896/
https://www.ncbi.nlm.nih.gov/pubmed/27013965
http://dx.doi.org/10.3389/fnmol.2016.00018

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