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Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea

PURPOSE: The purpose of this study was to assess the safety and early outcomes of the Pipeline device for large/giant or fusiform aneurysms. MATERIALS AND METHODS: The Pipeline was implanted in a total of 45 patients (mean age, 58 years; M:F=10:35) with 47 large/giant or fusiform aneurysms. We retro...

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Autores principales: Kim, Byung Moon, Shin, Yong Sam, Baik, Min Woo, Lee, Deok Hee, Jeon, Pyoung, Baik, Seung Kug, Lee, Tae Hong, Kang, Dong-Hoon, Suh, Sang-il, Byun, Jun Soo, Jung, Jin-Young, Kwon, Kihun, Kim, Dong Joon, Park, Keun Young, Kim, Bum-soo, Park, Jung Cheol, Kim, Seong Rim, Kim, Young Woo, Kim, Hoon, Jo, Kyungil, Yoon, Chang Hyo, Kim, Young Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Interventional Neuroradiology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781911/
https://www.ncbi.nlm.nih.gov/pubmed/26958407
http://dx.doi.org/10.5469/neuroint.2016.11.1.10
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author Kim, Byung Moon
Shin, Yong Sam
Baik, Min Woo
Lee, Deok Hee
Jeon, Pyoung
Baik, Seung Kug
Lee, Tae Hong
Kang, Dong-Hoon
Suh, Sang-il
Byun, Jun Soo
Jung, Jin-Young
Kwon, Kihun
Kim, Dong Joon
Park, Keun Young
Kim, Bum-soo
Park, Jung Cheol
Kim, Seong Rim
Kim, Young Woo
Kim, Hoon
Jo, Kyungil
Yoon, Chang Hyo
Kim, Young Soo
author_facet Kim, Byung Moon
Shin, Yong Sam
Baik, Min Woo
Lee, Deok Hee
Jeon, Pyoung
Baik, Seung Kug
Lee, Tae Hong
Kang, Dong-Hoon
Suh, Sang-il
Byun, Jun Soo
Jung, Jin-Young
Kwon, Kihun
Kim, Dong Joon
Park, Keun Young
Kim, Bum-soo
Park, Jung Cheol
Kim, Seong Rim
Kim, Young Woo
Kim, Hoon
Jo, Kyungil
Yoon, Chang Hyo
Kim, Young Soo
author_sort Kim, Byung Moon
collection PubMed
description PURPOSE: The purpose of this study was to assess the safety and early outcomes of the Pipeline device for large/giant or fusiform aneurysms. MATERIALS AND METHODS: The Pipeline was implanted in a total of 45 patients (mean age, 58 years; M:F=10:35) with 47 large/giant or fusiform aneurysms. We retrospectively evaluated the characteristics of the treated aneurysms, the periprocedural events, morbidity and mortality, and the early outcomes after Pipeline implantation. RESULTS: The aneurysms were located in the internal carotid artery (ICA) cavernous segment (n=25), ICA intradural segment (n=11), vertebrobasilar trunk (n=8), and middle cerebral artery (n=3). Procedure-related events occurred in 18 cases, consisting of incomplete expansion (n=8), shortening-migration (n=5), transient occlusion of a jailed branch (n=3), and in-stent thrombosis (n=2). Treatment-related morbidity occurred in two patients, but without mortality. Both patients had modified Rankin scale (mRS) scores of 2, but had an improved mRS score of 0 at 1-month follow-up. Of the 19 patients presenting with mass effect, 16 improved but three showed no changes in their presenting symptoms. All patients had excellent outcomes (mRS, 0 or 1) during the follow-up period (median, 6 months; range, 2-30 months). Vascular imaging follow-up (n=31, 65.9%; median, 3 months, range, 1-25 months) showed complete or near occlusion of the aneurysm in 24 patients (77.4%) and decreased sac size in seven patients (22.6%). CONCLUSION: In this initial multicenter study in Korea, the Pipeline seemed to be safe and effective for large/giant or fusiform aneurysms. However, a learning period may be required to alleviate device-related events.
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spelling pubmed-47819112016-03-08 Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea Kim, Byung Moon Shin, Yong Sam Baik, Min Woo Lee, Deok Hee Jeon, Pyoung Baik, Seung Kug Lee, Tae Hong Kang, Dong-Hoon Suh, Sang-il Byun, Jun Soo Jung, Jin-Young Kwon, Kihun Kim, Dong Joon Park, Keun Young Kim, Bum-soo Park, Jung Cheol Kim, Seong Rim Kim, Young Woo Kim, Hoon Jo, Kyungil Yoon, Chang Hyo Kim, Young Soo Neurointervention Original Paper PURPOSE: The purpose of this study was to assess the safety and early outcomes of the Pipeline device for large/giant or fusiform aneurysms. MATERIALS AND METHODS: The Pipeline was implanted in a total of 45 patients (mean age, 58 years; M:F=10:35) with 47 large/giant or fusiform aneurysms. We retrospectively evaluated the characteristics of the treated aneurysms, the periprocedural events, morbidity and mortality, and the early outcomes after Pipeline implantation. RESULTS: The aneurysms were located in the internal carotid artery (ICA) cavernous segment (n=25), ICA intradural segment (n=11), vertebrobasilar trunk (n=8), and middle cerebral artery (n=3). Procedure-related events occurred in 18 cases, consisting of incomplete expansion (n=8), shortening-migration (n=5), transient occlusion of a jailed branch (n=3), and in-stent thrombosis (n=2). Treatment-related morbidity occurred in two patients, but without mortality. Both patients had modified Rankin scale (mRS) scores of 2, but had an improved mRS score of 0 at 1-month follow-up. Of the 19 patients presenting with mass effect, 16 improved but three showed no changes in their presenting symptoms. All patients had excellent outcomes (mRS, 0 or 1) during the follow-up period (median, 6 months; range, 2-30 months). Vascular imaging follow-up (n=31, 65.9%; median, 3 months, range, 1-25 months) showed complete or near occlusion of the aneurysm in 24 patients (77.4%) and decreased sac size in seven patients (22.6%). CONCLUSION: In this initial multicenter study in Korea, the Pipeline seemed to be safe and effective for large/giant or fusiform aneurysms. However, a learning period may be required to alleviate device-related events. Korean Society of Interventional Neuroradiology 2016-03 2016-03-03 /pmc/articles/PMC4781911/ /pubmed/26958407 http://dx.doi.org/10.5469/neuroint.2016.11.1.10 Text en Copyright © 2016 Korean Society of Interventional Neuroradiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Kim, Byung Moon
Shin, Yong Sam
Baik, Min Woo
Lee, Deok Hee
Jeon, Pyoung
Baik, Seung Kug
Lee, Tae Hong
Kang, Dong-Hoon
Suh, Sang-il
Byun, Jun Soo
Jung, Jin-Young
Kwon, Kihun
Kim, Dong Joon
Park, Keun Young
Kim, Bum-soo
Park, Jung Cheol
Kim, Seong Rim
Kim, Young Woo
Kim, Hoon
Jo, Kyungil
Yoon, Chang Hyo
Kim, Young Soo
Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea
title Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea
title_full Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea
title_fullStr Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea
title_full_unstemmed Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea
title_short Pipeline Embolization Device for Large/Giant or Fusiform Aneurysms: An Initial Multi-Center Experience in Korea
title_sort pipeline embolization device for large/giant or fusiform aneurysms: an initial multi-center experience in korea
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781911/
https://www.ncbi.nlm.nih.gov/pubmed/26958407
http://dx.doi.org/10.5469/neuroint.2016.11.1.10
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