Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents

Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colon...

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Autores principales: Harris, R. Alan, Shah, Rajesh, Hollister, Emily B., Tronstad, Rune Rose, Hovdenak, Nils, Szigeti, Reka, Versalovic, James, Kellermayer, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781967/
https://www.ncbi.nlm.nih.gov/pubmed/27006956
http://dx.doi.org/10.1155/2016/9170162
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author Harris, R. Alan
Shah, Rajesh
Hollister, Emily B.
Tronstad, Rune Rose
Hovdenak, Nils
Szigeti, Reka
Versalovic, James
Kellermayer, Richard
author_facet Harris, R. Alan
Shah, Rajesh
Hollister, Emily B.
Tronstad, Rune Rose
Hovdenak, Nils
Szigeti, Reka
Versalovic, James
Kellermayer, Richard
author_sort Harris, R. Alan
collection PubMed
description Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.
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spelling pubmed-47819672016-03-22 Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents Harris, R. Alan Shah, Rajesh Hollister, Emily B. Tronstad, Rune Rose Hovdenak, Nils Szigeti, Reka Versalovic, James Kellermayer, Richard J Immunol Res Research Article Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC. Hindawi Publishing Corporation 2016 2016-02-23 /pmc/articles/PMC4781967/ /pubmed/27006956 http://dx.doi.org/10.1155/2016/9170162 Text en Copyright © 2016 R. Alan Harris et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Harris, R. Alan
Shah, Rajesh
Hollister, Emily B.
Tronstad, Rune Rose
Hovdenak, Nils
Szigeti, Reka
Versalovic, James
Kellermayer, Richard
Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
title Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
title_full Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
title_fullStr Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
title_full_unstemmed Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
title_short Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents
title_sort colonic mucosal epigenome and microbiome development in children and adolescents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781967/
https://www.ncbi.nlm.nih.gov/pubmed/27006956
http://dx.doi.org/10.1155/2016/9170162
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