Cargando…

GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-κB Pathway

Nonresolving inflammation is one of the consistent features of the tumor microenvironment in the intestine and plays a critical role in the initiation and development of colon cancer. Here we reported the inhibitory effects of GEN-27, a new derivative of genistein, on the inflammation-related colon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yajing, Lu, Ping, Zhang, Weifeng, Du, Qianming, Tang, Jingjing, Wang, Hong, Lu, Jinrong, Hu, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781992/ https://www.ncbi.nlm.nih.gov/pubmed/27057094 http://dx.doi.org/10.1155/2016/2853040

Ejemplares similares

Chemopreventive activity of GEN-27, a genistein derivative, in colitis-associated cancer is mediated by p65-CDX2-β-catenin axis
por: Du, Qianming, et al.
Publicado: (2016)

Rab27A mediated by NF-κB promotes the stemness of colon cancer cells via up-regulation of cytokine secretion
por: Feng, Feixue, et al.
Publicado: (2016)

Isoflavonoid-Antibiotic Thin Films Fabricated by MAPLE with Improved Resistance to Microbial Colonization
por: Grumezescu, Valentina, et al.
Publicado: (2021)

Lignans and isoflavonoids from the stems of Pisonia umbellifera
por: Liu, Zhiguo, et al.
Publicado: (2018)

Multiple hydride reduction pathways in isoflavonoids
por: Salakka, Auli K, et al.
Publicado: (2006)

Glucosylation of Isoflavonoids in Engineered Escherichia coli
por: Pandey, Ramesh Prasad, et al.
Publicado: (2014)

Crosstalk between the CBM complex/NF-κB and MAPK/P27 signaling pathways of regulatory T cells contributes to the tumor microenvironment
por: Qi, Tongbing, et al.
Publicado: (2022)

The impact of dietary isoflavonoids on malignant brain tumors
por: Sehm, Tina, et al.
Publicado: (2014)

Substituent Effects on the Radical Scavenging Activity of Isoflavonoid
por: Zheng, Yan-Zhen, et al.
Publicado: (2019)

Essential Elements and Isoflavonoids in the Prevention of Prostate Cancer
por: Stanisławska, Iwona J., et al.
Publicado: (2022)

New Synthetic Pyridine Derivate as Potential Elicitor in Production of Isoflavonoids and Flavonoids in Trifolium pratense L. Suspension Culture
por: Kašparová, Marie, et al.
Publicado: (2012)

Isolation and characterization of GmMYBJ3, an R2R3-MYB transcription factor that affects isoflavonoids biosynthesis in soybean
por: Zhao, Mingzhu, et al.
Publicado: (2017)

Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
por: Nirvanappa, Anilkumar C., et al.
Publicado: (2016)

Naturally Occurring Flavonoids and Isoflavonoids and Their Microbial Transformation: A Review
por: Wang, Jun-Fei, et al.
Publicado: (2020)

Isoflavonoids – an overview of their biological activities and potential health benefits
por: Miadoková, Eva
Publicado: (2009)

Medicinal Potential of Isoflavonoids: Polyphenols That May Cure Diabetes
por: Ahmed, Qamar Uddin, et al.
Publicado: (2020)

Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity
por: Toktay, Erdem, et al.
Publicado: (2020)

LZ-207, a Newly Synthesized Flavonoid, Induces Apoptosis and Suppresses Inflammation-Related Colon Cancer by Inhibiting the NF-κB Signaling Pathway
por: Sun, Jie, et al.
Publicado: (2015)

Polysubstituted Isoflavonoids from Spatholobus suberectus, Flemingia macrophylla, and Cudrania cochinchinensis
por: Wang, Li-Xia, et al.
Publicado: (2017)

Evolutionary study of the isoflavonoid pathway based on multiple copies analysis in soybean
por: Chu, Shanshan, et al.
Publicado: (2014)

New isoflavonoids from Erythrina arborescens and structure revision of anagyroidisoflavone A
por: Wang, Fei, et al.
Publicado: (2013)

Correction: Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo
por: Nirvanappa, Anilkumar C., et al.
Publicado: (2017)

Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs)
por: Wang, Zhipeng, et al.
Publicado: (2018)

The inhibition of the estrogenic effects of pesticides and environmental chemicals by curcumin and isoflavonoids.
por: Verma, S P, et al.
Publicado: (1998)

Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora
por: Promden, Worrawat, et al.
Publicado: (2014)

A Pharmacological Overview of Alpinumisoflavone, a Natural Prenylated Isoflavonoid
por: Ateba, Sylvin Benjamin, et al.
Publicado: (2019)

Discovery of isoflavone phytoalexins in wheat reveals an alternative route to isoflavonoid biosynthesis
por: Polturak, Guy, et al.
Publicado: (2023)

Radical Scavenging Capability and Mechanism of Three Isoflavonoids Extracted from Radix Astragali: A Theoretical Study
por: Lu, Xiao-Qin, et al.
Publicado: (2023)

Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-κB signaling
por: Tong, Haibo, et al.
Publicado: (2018)

Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence
por: Lund, Trent D, et al.
Publicado: (2011)

Effect of ultrasound on the isoflavonoid production in Genista tinctoria L. suspension cultures
por: Tůmová, Lenka, et al.
Publicado: (2014)

Quantitative Structure-Antioxidant Activity Models of Isoflavonoids: A Theoretical Study
por: Castellano, Gloria, et al.
Publicado: (2015)

GmMYB176 Regulates Multiple Steps in Isoflavonoid Biosynthesis in Soybean
por: Anguraj Vadivel, Arun Kumaran, et al.
Publicado: (2019)

De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories
por: Liu, Quanli, et al.
Publicado: (2021)

Wogonoside prevents colitis-associated colorectal carcinogenesis and colon cancer progression in inflammation-related microenvironment via inhibiting NF-κB activation through PI3K/Akt pathway
por: Sun, Yang, et al.
Publicado: (2016)

Colon contradictions: NF-κB signaling in intestinal tumorigenesis
por: Fordham, Robert P., et al.
Publicado: (2015)

Brain Pharmacokinetics and the Pharmacological Effects on Striatal Neurotransmitter Levels of Pueraria lobata Isoflavonoids in Rat
por: Xiao, Bingxin, et al.
Publicado: (2017)

EV-Mediated Chemoresistance in the Tumor Microenvironment: Is NF-κB a Player?
por: Di Vito Nolfi, Mauro, et al.
Publicado: (2022)

NF-κB mediated regulation of tumor cell proliferation in hypoxic microenvironment
por: Rastogi, Shubham, et al.
Publicado: (2023)

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer
por: Prabhu, Lakshmi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_k5gv9f5a4ta2o25pkcovuuf17i