Making choices—how stochastic decisions determine disease progression

In this issue of Genes & Development, Ginart and colleagues (pp. 567–578) study a mouse model for Russell-Silver syndrome (RSS) and show that similar cells within one individual can display distinct gene expression patterns because of epigenetic marks that are established stochastically during e...

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Detalles Bibliográficos
Autores principales: Park, Ki-Sun, Pfeifer, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782042/
https://www.ncbi.nlm.nih.gov/pubmed/26944674
http://dx.doi.org/10.1101/gad.278952.116
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author Park, Ki-Sun
Pfeifer, Karl
author_facet Park, Ki-Sun
Pfeifer, Karl
author_sort Park, Ki-Sun
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description In this issue of Genes & Development, Ginart and colleagues (pp. 567–578) study a mouse model for Russell-Silver syndrome (RSS) and show that similar cells within one individual can display distinct gene expression patterns because of epigenetic marks that are established stochastically during early development. Their results provide an excellent explanation for phenotypes seen in RSS and other imprinting disorders and especially help us understand how patients with similar or even identical genetic mutations can display distinct disease profiles.
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spelling pubmed-47820422016-09-01 Making choices—how stochastic decisions determine disease progression Park, Ki-Sun Pfeifer, Karl Genes Dev Outlook In this issue of Genes & Development, Ginart and colleagues (pp. 567–578) study a mouse model for Russell-Silver syndrome (RSS) and show that similar cells within one individual can display distinct gene expression patterns because of epigenetic marks that are established stochastically during early development. Their results provide an excellent explanation for phenotypes seen in RSS and other imprinting disorders and especially help us understand how patients with similar or even identical genetic mutations can display distinct disease profiles. Cold Spring Harbor Laboratory Press 2016-03-01 /pmc/articles/PMC4782042/ /pubmed/26944674 http://dx.doi.org/10.1101/gad.278952.116 Text en Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Park, Ki-Sun
Pfeifer, Karl
Making choices—how stochastic decisions determine disease progression
title Making choices—how stochastic decisions determine disease progression
title_full Making choices—how stochastic decisions determine disease progression
title_fullStr Making choices—how stochastic decisions determine disease progression
title_full_unstemmed Making choices—how stochastic decisions determine disease progression
title_short Making choices—how stochastic decisions determine disease progression
title_sort making choices—how stochastic decisions determine disease progression
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782042/
https://www.ncbi.nlm.nih.gov/pubmed/26944674
http://dx.doi.org/10.1101/gad.278952.116
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