Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock

How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Müller-McNicoll and colleagues (pp. 553–566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alter...

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Detalles Bibliográficos
Autores principales: Elbarbary, Reyad A., Maquat, Lynne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782043/
https://www.ncbi.nlm.nih.gov/pubmed/26944675
http://dx.doi.org/10.1101/gad.278937.116
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author Elbarbary, Reyad A.
Maquat, Lynne E.
author_facet Elbarbary, Reyad A.
Maquat, Lynne E.
author_sort Elbarbary, Reyad A.
collection PubMed
description How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Müller-McNicoll and colleagues (pp. 553–566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm.
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spelling pubmed-47820432016-09-01 Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock Elbarbary, Reyad A. Maquat, Lynne E. Genes Dev Outlook How does a mammalian cell determine when newly synthesized mRNAs are fully processed and appropriate for nuclear export? Müller-McNicoll and colleagues (pp. 553–566) expand on mechanisms known to be mediated by nuclear export factor 1 (NXF1) by describing SR proteins as NXF1 adaptors that flag alternatively spliced and polyadenylated mRNA isoforms as cargo ready for the cytoplasm. Cold Spring Harbor Laboratory Press 2016-03-01 /pmc/articles/PMC4782043/ /pubmed/26944675 http://dx.doi.org/10.1101/gad.278937.116 Text en © 2016 Elbarbary and Maquat; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Elbarbary, Reyad A.
Maquat, Lynne E.
Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
title Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
title_full Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
title_fullStr Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
title_full_unstemmed Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
title_short Coupling pre-mRNA splicing and 3′ end formation to mRNA export: alternative ways to punch the nuclear export clock
title_sort coupling pre-mrna splicing and 3′ end formation to mrna export: alternative ways to punch the nuclear export clock
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782043/
https://www.ncbi.nlm.nih.gov/pubmed/26944675
http://dx.doi.org/10.1101/gad.278937.116
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