Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant

Imprinting is a classic mammalian epigenetic phenomenon that results in expression from a single parental allele. Imprinting defects can lead to inappropriate expression from the normally silenced allele, but it remains unclear whether every cell in a mutant organism follows the population average,...

Descripción completa

Detalles Bibliográficos
Autores principales: Ginart, Paul, Kalish, Jennifer M., Jiang, Connie L., Yu, Alice C., Bartolomei, Marisa S., Raj, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782050/
https://www.ncbi.nlm.nih.gov/pubmed/26944681
http://dx.doi.org/10.1101/gad.275958.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782050/
https://www.ncbi.nlm.nih.gov/pubmed/26944681
http://dx.doi.org/10.1101/gad.275958.115

Ejemplares similares