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Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain
Exposure of infant animals, including non-human primates (NHPs), to anaesthetic drugs causes apoptotic death of neurons and oligodendrocytes (oligos) and results in long-term neurodevelopmental impairment (NDI). Moreover, retrospective clinical studies document an association between anaesthesia exp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782073/ https://www.ncbi.nlm.nih.gov/pubmed/26951756 http://dx.doi.org/10.1038/srep22427 |
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author | Noguchi, Kevin K. Johnson, Stephen A. Kristich, Lauren E. Martin, Lauren D. Dissen, Gregory A. Olsen, Emily A. Olney, John W. Brambrink, Ansgar M. |
author_facet | Noguchi, Kevin K. Johnson, Stephen A. Kristich, Lauren E. Martin, Lauren D. Dissen, Gregory A. Olsen, Emily A. Olney, John W. Brambrink, Ansgar M. |
author_sort | Noguchi, Kevin K. |
collection | PubMed |
description | Exposure of infant animals, including non-human primates (NHPs), to anaesthetic drugs causes apoptotic death of neurons and oligodendrocytes (oligos) and results in long-term neurodevelopmental impairment (NDI). Moreover, retrospective clinical studies document an association between anaesthesia exposure of human infants and significant increase in NDI. These findings pose a potentially serious dilemma because millions of human infants are exposed to anaesthetic drugs every year as part of routine medical care. Lithium (Li) at clinically established doses is neuroprotective in various cerebral injury models. We therefore investigated whether Li also protects against anaesthesia neurotoxicity in infant NHPs. On postnatal day 6 NHPs were anaesthetized with the widely used anaesthetic isoflurane (ISO) for 5 h employing the same standards as in a human pediatric surgery setting. Co-administration of Li completely prevented the acute ISO-induced neuroapoptosis and significantly reduced ISO-induced apoptosis of oligodendroglia. Our findings are highly encouraging as they suggest that a relatively simple pharmacological manipulation might protect the developing primate brain against the neurotoxic action of anaesthetic drugs while not interfering with the beneficial actions of these drugs. Further research is needed to determine Li’s potential to prevent long-term NDI resulting from ISO anaesthesia, and to establish its safety in human infants. |
format | Online Article Text |
id | pubmed-4782073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47820732016-03-09 Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain Noguchi, Kevin K. Johnson, Stephen A. Kristich, Lauren E. Martin, Lauren D. Dissen, Gregory A. Olsen, Emily A. Olney, John W. Brambrink, Ansgar M. Sci Rep Article Exposure of infant animals, including non-human primates (NHPs), to anaesthetic drugs causes apoptotic death of neurons and oligodendrocytes (oligos) and results in long-term neurodevelopmental impairment (NDI). Moreover, retrospective clinical studies document an association between anaesthesia exposure of human infants and significant increase in NDI. These findings pose a potentially serious dilemma because millions of human infants are exposed to anaesthetic drugs every year as part of routine medical care. Lithium (Li) at clinically established doses is neuroprotective in various cerebral injury models. We therefore investigated whether Li also protects against anaesthesia neurotoxicity in infant NHPs. On postnatal day 6 NHPs were anaesthetized with the widely used anaesthetic isoflurane (ISO) for 5 h employing the same standards as in a human pediatric surgery setting. Co-administration of Li completely prevented the acute ISO-induced neuroapoptosis and significantly reduced ISO-induced apoptosis of oligodendroglia. Our findings are highly encouraging as they suggest that a relatively simple pharmacological manipulation might protect the developing primate brain against the neurotoxic action of anaesthetic drugs while not interfering with the beneficial actions of these drugs. Further research is needed to determine Li’s potential to prevent long-term NDI resulting from ISO anaesthesia, and to establish its safety in human infants. Nature Publishing Group 2016-03-08 /pmc/articles/PMC4782073/ /pubmed/26951756 http://dx.doi.org/10.1038/srep22427 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Noguchi, Kevin K. Johnson, Stephen A. Kristich, Lauren E. Martin, Lauren D. Dissen, Gregory A. Olsen, Emily A. Olney, John W. Brambrink, Ansgar M. Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain |
title | Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain |
title_full | Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain |
title_fullStr | Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain |
title_full_unstemmed | Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain |
title_short | Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain |
title_sort | lithium protects against anaesthesia neurotoxicity in the infant primate brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782073/ https://www.ncbi.nlm.nih.gov/pubmed/26951756 http://dx.doi.org/10.1038/srep22427 |
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