miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have pote...

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Detalles Bibliográficos
Autores principales: Atarod, Sadaf, Ahmed, Mohammed Mahid, Lendrem, Clare, Pearce, Kim Frances, Cope, Wei, Norden, Jean, Wang, Xiao-Nong, Collin, Matthew, Dickinson, Anne Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782155/
https://www.ncbi.nlm.nih.gov/pubmed/27014257
http://dx.doi.org/10.3389/fimmu.2016.00056
Descripción
Sumario:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.

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