miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have pote...

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Autores principales: Atarod, Sadaf, Ahmed, Mohammed Mahid, Lendrem, Clare, Pearce, Kim Frances, Cope, Wei, Norden, Jean, Wang, Xiao-Nong, Collin, Matthew, Dickinson, Anne Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782155/
https://www.ncbi.nlm.nih.gov/pubmed/27014257
http://dx.doi.org/10.3389/fimmu.2016.00056
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author Atarod, Sadaf
Ahmed, Mohammed Mahid
Lendrem, Clare
Pearce, Kim Frances
Cope, Wei
Norden, Jean
Wang, Xiao-Nong
Collin, Matthew
Dickinson, Anne Mary
author_facet Atarod, Sadaf
Ahmed, Mohammed Mahid
Lendrem, Clare
Pearce, Kim Frances
Cope, Wei
Norden, Jean
Wang, Xiao-Nong
Collin, Matthew
Dickinson, Anne Mary
author_sort Atarod, Sadaf
collection PubMed
description Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.
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spelling pubmed-47821552016-03-24 miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence Atarod, Sadaf Ahmed, Mohammed Mahid Lendrem, Clare Pearce, Kim Frances Cope, Wei Norden, Jean Wang, Xiao-Nong Collin, Matthew Dickinson, Anne Mary Front Immunol Immunology Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression. Frontiers Media S.A. 2016-03-08 /pmc/articles/PMC4782155/ /pubmed/27014257 http://dx.doi.org/10.3389/fimmu.2016.00056 Text en Copyright © 2016 Atarod, Ahmed, Lendrem, Pearce, Cope, Norden, Wang, Collin and Dickinson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Atarod, Sadaf
Ahmed, Mohammed Mahid
Lendrem, Clare
Pearce, Kim Frances
Cope, Wei
Norden, Jean
Wang, Xiao-Nong
Collin, Matthew
Dickinson, Anne Mary
miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
title miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
title_full miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
title_fullStr miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
title_full_unstemmed miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
title_short miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence
title_sort mir-146a and mir-155 expression levels in acute graft-versus-host disease incidence
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782155/
https://www.ncbi.nlm.nih.gov/pubmed/27014257
http://dx.doi.org/10.3389/fimmu.2016.00056
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