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Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity, and protein–protein interactions all contribute to determine how efficiently...

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Detalles Bibliográficos
Autores principales:	Kapoor-Kaushik, Natasha, Hinde, Elizabeth, Compeer, Ewoud B., Yamamoto, Yui, Kraus, Felix, Yang, Zhengmin, Lou, Jieqiong, Pageon, Sophie V., Tabarin, Thibault, Gaus, Katharina, Rossy, Jérémie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782156/ https://www.ncbi.nlm.nih.gov/pubmed/27014263 http://dx.doi.org/10.3389/fimmu.2016.00083

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