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HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know

Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immunogenic and safe in patients with SLE, even if antibody titres are frequently lower than tho...

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Autores principales: Grein, Ingrid Herta Rotstein, Groot, Noortje, Lacerda, Marcela Ignacchiti, Wulffraat, Nico, Pileggi, Gecilmara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782298/
https://www.ncbi.nlm.nih.gov/pubmed/26956735
http://dx.doi.org/10.1186/s12969-016-0072-x
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author Grein, Ingrid Herta Rotstein
Groot, Noortje
Lacerda, Marcela Ignacchiti
Wulffraat, Nico
Pileggi, Gecilmara
author_facet Grein, Ingrid Herta Rotstein
Groot, Noortje
Lacerda, Marcela Ignacchiti
Wulffraat, Nico
Pileggi, Gecilmara
author_sort Grein, Ingrid Herta Rotstein
collection PubMed
description Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immunogenic and safe in patients with SLE, even if antibody titres are frequently lower than those of healthy controls. Human papillomavirus (HPV) infections are more prevalent in SLE patients when compared to the healthy population. Low-risk types of this virus cause anogenital warts, while high risk types are strongly related to pre-malignant cervical abnormalities and cervical cancer. HPV vaccines have been developed to prevent these conditions. Although little is known about HPV vaccination in SLE, few studies in patients with autoimmune rheumatic diseases (AIRDs) have shown that HPV vaccines are safe, and capable to induce an immunogenic response in this group of patients. To date, available data suggest that HPV vaccines can be given safely to SLE patients. Given the increased incidence of cervical abnormalities due to HPV in SLE patients, this vaccination should be encouraged.
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spelling pubmed-47822982016-03-09 HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know Grein, Ingrid Herta Rotstein Groot, Noortje Lacerda, Marcela Ignacchiti Wulffraat, Nico Pileggi, Gecilmara Pediatr Rheumatol Online J Review Patients with Systemic Lupus Erythematosus (SLE) are at increased risk for infections. Vaccination is a powerful tool to prevent infections, even in immunocompromised patients. Most non-live vaccines are immunogenic and safe in patients with SLE, even if antibody titres are frequently lower than those of healthy controls. Human papillomavirus (HPV) infections are more prevalent in SLE patients when compared to the healthy population. Low-risk types of this virus cause anogenital warts, while high risk types are strongly related to pre-malignant cervical abnormalities and cervical cancer. HPV vaccines have been developed to prevent these conditions. Although little is known about HPV vaccination in SLE, few studies in patients with autoimmune rheumatic diseases (AIRDs) have shown that HPV vaccines are safe, and capable to induce an immunogenic response in this group of patients. To date, available data suggest that HPV vaccines can be given safely to SLE patients. Given the increased incidence of cervical abnormalities due to HPV in SLE patients, this vaccination should be encouraged. BioMed Central 2016-03-08 /pmc/articles/PMC4782298/ /pubmed/26956735 http://dx.doi.org/10.1186/s12969-016-0072-x Text en © Grein et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Grein, Ingrid Herta Rotstein
Groot, Noortje
Lacerda, Marcela Ignacchiti
Wulffraat, Nico
Pileggi, Gecilmara
HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
title HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
title_full HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
title_fullStr HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
title_full_unstemmed HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
title_short HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know
title_sort hpv infection and vaccination in systemic lupus erythematosus patients: what we really should know
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782298/
https://www.ncbi.nlm.nih.gov/pubmed/26956735
http://dx.doi.org/10.1186/s12969-016-0072-x
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