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Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

BACKGROUND: The Mre11-Rad50-Nbs1 (MRN) complex is well known for its crucial role in initiating DNA double strand breaks (DSBs) repair pathways to resistant irradiation (IR) injury and thus facilitating radioresistance which severely reduces radiocurability of nasopharyngeal cancer (NPC). Targeting...

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Detalles Bibliográficos
Autores principales:	Chang, Lihong, Huang, Jiancong, Wang, Kai, Li, Jingjia, Yan, Ruicheng, Zhu, Ling, Ye, Jin, Wu, Xifu, Zhuang, Shimin, Li, Daqing, Zhang, Gehua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782334/ https://www.ncbi.nlm.nih.gov/pubmed/26951044 http://dx.doi.org/10.1186/s12885-016-2190-8

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