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Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL)

BACKGROUND: Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogenous biospecimens off...

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Detalles Bibliográficos
Autores principales:	Koestler, Devin C., Jones, Meaghan J., Usset, Joseph, Christensen, Brock C., Butler, Rondi A., Kobor, Michael S., Wiencke, John K., Kelsey, Karl T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782368/ https://www.ncbi.nlm.nih.gov/pubmed/26956433 http://dx.doi.org/10.1186/s12859-016-0943-7

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