Adult-onset Leigh's disease: A rare entity

Leigh syndrome (LS) is a heterogeneous familial or sporadic neurodegenerative disorder. It is typically seen in infancy or childhood, although rare cases of adult onset have been described. The authors describe a 37-year-old woman who presented with protracted gastrointestinal symptoms followed by a...

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Autores principales: Jabeen, Shaik Afshan, Sandeep, G., Mridula, Kandadai Rukmini, Meena, Angamuttu Kanikannan, Borgohain, Rupam, Sundaram, Challa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782535/
https://www.ncbi.nlm.nih.gov/pubmed/27011650
http://dx.doi.org/10.4103/0972-2327.175437
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author Jabeen, Shaik Afshan
Sandeep, G.
Mridula, Kandadai Rukmini
Meena, Angamuttu Kanikannan
Borgohain, Rupam
Sundaram, Challa
author_facet Jabeen, Shaik Afshan
Sandeep, G.
Mridula, Kandadai Rukmini
Meena, Angamuttu Kanikannan
Borgohain, Rupam
Sundaram, Challa
author_sort Jabeen, Shaik Afshan
collection PubMed
description Leigh syndrome (LS) is a heterogeneous familial or sporadic neurodegenerative disorder. It is typically seen in infancy or childhood, although rare cases of adult onset have been described. The authors describe a 37-year-old woman who presented with protracted gastrointestinal symptoms followed by acute brain stem syndrome with severe metabolic acidosis and who subsequently showed dramatic clinical and neuroradiological improvement.
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spelling pubmed-47825352016-03-23 Adult-onset Leigh's disease: A rare entity Jabeen, Shaik Afshan Sandeep, G. Mridula, Kandadai Rukmini Meena, Angamuttu Kanikannan Borgohain, Rupam Sundaram, Challa Ann Indian Acad Neurol Case Report Leigh syndrome (LS) is a heterogeneous familial or sporadic neurodegenerative disorder. It is typically seen in infancy or childhood, although rare cases of adult onset have been described. The authors describe a 37-year-old woman who presented with protracted gastrointestinal symptoms followed by acute brain stem syndrome with severe metabolic acidosis and who subsequently showed dramatic clinical and neuroradiological improvement. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4782535/ /pubmed/27011650 http://dx.doi.org/10.4103/0972-2327.175437 Text en Copyright: © 2016 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Jabeen, Shaik Afshan
Sandeep, G.
Mridula, Kandadai Rukmini
Meena, Angamuttu Kanikannan
Borgohain, Rupam
Sundaram, Challa
Adult-onset Leigh's disease: A rare entity
title Adult-onset Leigh's disease: A rare entity
title_full Adult-onset Leigh's disease: A rare entity
title_fullStr Adult-onset Leigh's disease: A rare entity
title_full_unstemmed Adult-onset Leigh's disease: A rare entity
title_short Adult-onset Leigh's disease: A rare entity
title_sort adult-onset leigh's disease: a rare entity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782535/
https://www.ncbi.nlm.nih.gov/pubmed/27011650
http://dx.doi.org/10.4103/0972-2327.175437
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