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Association of ACE Gene I/D polymorphism with migraine in Kashmiri population

INTRODUCTION: Migraine is a complex, recurrent headache disorder that is one of the most common complaints in neurology practice. The role of various genes in its pathogenesis is being studied. We did this study to see whether an association exists between ACE gene I/D polymorphism and migraine in o...

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Autores principales: Wani, Irfan Yousuf, Sheikh, Saleem, Shah, Zafar Amin, Pandith, Arshid A., Wani, Mushtaq, Asimi, Ravouf, Wani, Maqbool, Sheikh, Shahnawaz, Mehraj, Iqra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782560/
https://www.ncbi.nlm.nih.gov/pubmed/27011636
http://dx.doi.org/10.4103/0972-2327.167698
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author Wani, Irfan Yousuf
Sheikh, Saleem
Shah, Zafar Amin
Pandith, Arshid A.
Wani, Mushtaq
Asimi, Ravouf
Wani, Maqbool
Sheikh, Shahnawaz
Mehraj, Iqra
author_facet Wani, Irfan Yousuf
Sheikh, Saleem
Shah, Zafar Amin
Pandith, Arshid A.
Wani, Mushtaq
Asimi, Ravouf
Wani, Maqbool
Sheikh, Shahnawaz
Mehraj, Iqra
author_sort Wani, Irfan Yousuf
collection PubMed
description INTRODUCTION: Migraine is a complex, recurrent headache disorder that is one of the most common complaints in neurology practice. The role of various genes in its pathogenesis is being studied. We did this study to see whether an association exists between ACE gene I/D polymorphism and migraine in our region. MATERIALS AND METHODS: The study included 100 patients diagnosed with migraine and 121 healthy controls. The study subject were age and gender matched. The analysis was based on Polymerase Chain Reaction (PCR) and included following steps: DNA extraction from blood, PCR and Restriction Fragment Length Polymorphism (RFLP). RESULTS: Out of 100 cases, 69 were females and 31 were males. Fifty-seven were having migraine without aura and 43 had migraine with aura. 45 of the cases had II polymorphism, 40 had ID polymorphism and 15 had DD polymorphism in ACE gene. CONCLUSION: We were not able to find a statistically significant association between ACE gene I/D polymorphism with migraine. The reason for difference in results between our study and other studies could be because of different ethnicity in study populations. So a continuous research is needed in this regard in order to find the genes and different polymorphism that increase the susceptibility of Kashmiri population to migraine.
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spelling pubmed-47825602016-03-23 Association of ACE Gene I/D polymorphism with migraine in Kashmiri population Wani, Irfan Yousuf Sheikh, Saleem Shah, Zafar Amin Pandith, Arshid A. Wani, Mushtaq Asimi, Ravouf Wani, Maqbool Sheikh, Shahnawaz Mehraj, Iqra Ann Indian Acad Neurol Original Article INTRODUCTION: Migraine is a complex, recurrent headache disorder that is one of the most common complaints in neurology practice. The role of various genes in its pathogenesis is being studied. We did this study to see whether an association exists between ACE gene I/D polymorphism and migraine in our region. MATERIALS AND METHODS: The study included 100 patients diagnosed with migraine and 121 healthy controls. The study subject were age and gender matched. The analysis was based on Polymerase Chain Reaction (PCR) and included following steps: DNA extraction from blood, PCR and Restriction Fragment Length Polymorphism (RFLP). RESULTS: Out of 100 cases, 69 were females and 31 were males. Fifty-seven were having migraine without aura and 43 had migraine with aura. 45 of the cases had II polymorphism, 40 had ID polymorphism and 15 had DD polymorphism in ACE gene. CONCLUSION: We were not able to find a statistically significant association between ACE gene I/D polymorphism with migraine. The reason for difference in results between our study and other studies could be because of different ethnicity in study populations. So a continuous research is needed in this regard in order to find the genes and different polymorphism that increase the susceptibility of Kashmiri population to migraine. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4782560/ /pubmed/27011636 http://dx.doi.org/10.4103/0972-2327.167698 Text en Copyright: © 2016 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Wani, Irfan Yousuf
Sheikh, Saleem
Shah, Zafar Amin
Pandith, Arshid A.
Wani, Mushtaq
Asimi, Ravouf
Wani, Maqbool
Sheikh, Shahnawaz
Mehraj, Iqra
Association of ACE Gene I/D polymorphism with migraine in Kashmiri population
title Association of ACE Gene I/D polymorphism with migraine in Kashmiri population
title_full Association of ACE Gene I/D polymorphism with migraine in Kashmiri population
title_fullStr Association of ACE Gene I/D polymorphism with migraine in Kashmiri population
title_full_unstemmed Association of ACE Gene I/D polymorphism with migraine in Kashmiri population
title_short Association of ACE Gene I/D polymorphism with migraine in Kashmiri population
title_sort association of ace gene i/d polymorphism with migraine in kashmiri population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782560/
https://www.ncbi.nlm.nih.gov/pubmed/27011636
http://dx.doi.org/10.4103/0972-2327.167698
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