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Psoriasis: new comorbidities

Psoriasis is a chronic inflammatory disease associated with several comorbidities. A few decades ago, it was considered an exclusive skin disease but today it is considered a multisystem disease. It is believed that 73% of psoriasis patients have at least one comorbidity. Studies have demonstrated t...

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Autores principales: Machado-Pinto, Jackson, Diniz, Michelle dos Santos, Bavoso, Nádia Couto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782640/
https://www.ncbi.nlm.nih.gov/pubmed/26982772
http://dx.doi.org/10.1590/abd1806-4841.20164169
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author Machado-Pinto, Jackson
Diniz, Michelle dos Santos
Bavoso, Nádia Couto
author_facet Machado-Pinto, Jackson
Diniz, Michelle dos Santos
Bavoso, Nádia Couto
author_sort Machado-Pinto, Jackson
collection PubMed
description Psoriasis is a chronic inflammatory disease associated with several comorbidities. A few decades ago, it was considered an exclusive skin disease but today it is considered a multisystem disease. It is believed that 73% of psoriasis patients have at least one comorbidity. Studies have demonstrated the association of psoriasis with inflammatory bowel disease, uveitis, psychiatric disorders, metabolic syndrome and its components and cardiovascular diseases. The systemic inflammatory state seems to be the common denominator for all these comorbidities. This work aims at presenting a review of the current literature on some new comorbidities that are associated with psoriasis as osteoporosis, obstructive sleep apnea and chronic obstructive pulmonary disease. While there is still controversy, many studies already point to a possible bone involvement in patients with psoriasis, especially in the male group, generally less affected by osteoporosis. Psoriasis and chronic obstructive pulmonary disease present some risk factors in common as obesity, smoking and physical inactivity. Besides, both diseases are associated with the metabolic syndrome. These factors could be potential confounders in the association of the two diseases. Further prospective studies with control of those potential confounders should be developed in an attempt to establish causality. Existing data in the literature suggest that there is an association between obstructive sleep apnea and psoriasis, but studies performed until now have involved few patients and had a short follow-up period. It is, therefore, premature to assert that there is indeed a correlation between these two diseases.
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spelling pubmed-47826402016-03-10 Psoriasis: new comorbidities Machado-Pinto, Jackson Diniz, Michelle dos Santos Bavoso, Nádia Couto An Bras Dermatol Continuing Medical Education Psoriasis is a chronic inflammatory disease associated with several comorbidities. A few decades ago, it was considered an exclusive skin disease but today it is considered a multisystem disease. It is believed that 73% of psoriasis patients have at least one comorbidity. Studies have demonstrated the association of psoriasis with inflammatory bowel disease, uveitis, psychiatric disorders, metabolic syndrome and its components and cardiovascular diseases. The systemic inflammatory state seems to be the common denominator for all these comorbidities. This work aims at presenting a review of the current literature on some new comorbidities that are associated with psoriasis as osteoporosis, obstructive sleep apnea and chronic obstructive pulmonary disease. While there is still controversy, many studies already point to a possible bone involvement in patients with psoriasis, especially in the male group, generally less affected by osteoporosis. Psoriasis and chronic obstructive pulmonary disease present some risk factors in common as obesity, smoking and physical inactivity. Besides, both diseases are associated with the metabolic syndrome. These factors could be potential confounders in the association of the two diseases. Further prospective studies with control of those potential confounders should be developed in an attempt to establish causality. Existing data in the literature suggest that there is an association between obstructive sleep apnea and psoriasis, but studies performed until now have involved few patients and had a short follow-up period. It is, therefore, premature to assert that there is indeed a correlation between these two diseases. Sociedade Brasileira de Dermatologia 2016 /pmc/articles/PMC4782640/ /pubmed/26982772 http://dx.doi.org/10.1590/abd1806-4841.20164169 Text en © 2016 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Continuing Medical Education
Machado-Pinto, Jackson
Diniz, Michelle dos Santos
Bavoso, Nádia Couto
Psoriasis: new comorbidities
title Psoriasis: new comorbidities
title_full Psoriasis: new comorbidities
title_fullStr Psoriasis: new comorbidities
title_full_unstemmed Psoriasis: new comorbidities
title_short Psoriasis: new comorbidities
title_sort psoriasis: new comorbidities
topic Continuing Medical Education
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782640/
https://www.ncbi.nlm.nih.gov/pubmed/26982772
http://dx.doi.org/10.1590/abd1806-4841.20164169
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