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Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo
BACKGROUND: Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4. OBJECTIVES: To examine the associ...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782642/ https://www.ncbi.nlm.nih.gov/pubmed/26982774 http://dx.doi.org/10.1590/abd1806-4841.20163941 |
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author | Cuevas-Gonzalez, Juan Carlos Lievanos-Estrada, Zahide Vega-Memije, Maria Elisa Hojyo-Tomoka, Maria Teresa Dominguez-Soto, Luciano |
author_facet | Cuevas-Gonzalez, Juan Carlos Lievanos-Estrada, Zahide Vega-Memije, Maria Elisa Hojyo-Tomoka, Maria Teresa Dominguez-Soto, Luciano |
author_sort | Cuevas-Gonzalez, Juan Carlos |
collection | PubMed |
description | BACKGROUND: Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4. OBJECTIVES: To examine the association of serum IgE levels and the clinical severity of injuries. METHODS: This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay. Cases were classified by lesion severity as mild, moderate, and severe. Descriptive statistics were analyzed, and chi-square test was performed. RESULTS: We included 21 actinic prurigo patients and 21 subjects without disease; 11 patients with actinic prurigo had elevated serum IgE levels, and 10 had low serum levels. Six actinic prurigo (AP) patients with elevated serum levels of IgE had moderate injuries, 4 had severe injuries, and 1 had minor injuries. Eight out of 10 patients with normal IgE levels presented with minor injuries in the clinical evaluation. The 21 controls did not have increased serum IgE levels. CONCLUSIONS: Elevated IgE levels are associated with moderate to severe clinical lesions, suggesting that actinic prurigo entails a type IV subtype b hypersensitivity response in which Th2 cells predominate. |
format | Online Article Text |
id | pubmed-4782642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-47826422016-03-10 Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo Cuevas-Gonzalez, Juan Carlos Lievanos-Estrada, Zahide Vega-Memije, Maria Elisa Hojyo-Tomoka, Maria Teresa Dominguez-Soto, Luciano An Bras Dermatol Investigation BACKGROUND: Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4. OBJECTIVES: To examine the association of serum IgE levels and the clinical severity of injuries. METHODS: This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subjects, from whom 3cc of peripheral blood was taken for immunoassay. Cases were classified by lesion severity as mild, moderate, and severe. Descriptive statistics were analyzed, and chi-square test was performed. RESULTS: We included 21 actinic prurigo patients and 21 subjects without disease; 11 patients with actinic prurigo had elevated serum IgE levels, and 10 had low serum levels. Six actinic prurigo (AP) patients with elevated serum levels of IgE had moderate injuries, 4 had severe injuries, and 1 had minor injuries. Eight out of 10 patients with normal IgE levels presented with minor injuries in the clinical evaluation. The 21 controls did not have increased serum IgE levels. CONCLUSIONS: Elevated IgE levels are associated with moderate to severe clinical lesions, suggesting that actinic prurigo entails a type IV subtype b hypersensitivity response in which Th2 cells predominate. Sociedade Brasileira de Dermatologia 2016 /pmc/articles/PMC4782642/ /pubmed/26982774 http://dx.doi.org/10.1590/abd1806-4841.20163941 Text en © 2016 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Investigation Cuevas-Gonzalez, Juan Carlos Lievanos-Estrada, Zahide Vega-Memije, Maria Elisa Hojyo-Tomoka, Maria Teresa Dominguez-Soto, Luciano Correlation of serum IgE levels and clinical manifestations in patients with actinic prurigo |
title | Correlation of serum IgE levels and clinical manifestations in
patients with actinic prurigo
|
title_full | Correlation of serum IgE levels and clinical manifestations in
patients with actinic prurigo
|
title_fullStr | Correlation of serum IgE levels and clinical manifestations in
patients with actinic prurigo
|
title_full_unstemmed | Correlation of serum IgE levels and clinical manifestations in
patients with actinic prurigo
|
title_short | Correlation of serum IgE levels and clinical manifestations in
patients with actinic prurigo
|
title_sort | correlation of serum ige levels and clinical manifestations in
patients with actinic prurigo |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782642/ https://www.ncbi.nlm.nih.gov/pubmed/26982774 http://dx.doi.org/10.1590/abd1806-4841.20163941 |
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