Design, Synthesis, and Evaluation of Irciniastatin Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents

[Image: see text] The design, synthesis, and biological evaluation of irciniastatin A (1) analogues, achieved by removal of three synthetically challenging structural units, as well as by functional group manipulation of the C(11) substituent of both irciniastatins A and B (1 and 2), has been achiev...

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Detalles Bibliográficos
Autores principales: Liu, Qi, An, Chihui, TenDyke, Karen, Cheng, Hongsheng, Shen, Young Yongchun, Hoye, Adam T., Smith, Amos B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782725/
https://www.ncbi.nlm.nih.gov/pubmed/26879056
http://dx.doi.org/10.1021/acs.joc.5b02771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782725/
https://www.ncbi.nlm.nih.gov/pubmed/26879056
http://dx.doi.org/10.1021/acs.joc.5b02771

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