The role of leptin in central nervous system diseases

Leptin is a peptide hormone produced by adipose tissue and acts in brain centers to control critical physiological functions. Leptin receptors are especially abundant in the hypothalamus and trigger specific neuronal subpopulations, and activate several intracellular signaling events, including the...

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Detalles Bibliográficos
Autores principales: Li, Xiao-Mei, Yan, Hai-Jing, Guo, Yi-Shan, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Clinical Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782820/
https://www.ncbi.nlm.nih.gov/pubmed/26885866
http://dx.doi.org/10.1097/WNR.0000000000000546
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author Li, Xiao-Mei
Yan, Hai-Jing
Guo, Yi-Shan
Wang, Dong
author_facet Li, Xiao-Mei
Yan, Hai-Jing
Guo, Yi-Shan
Wang, Dong
author_sort Li, Xiao-Mei
collection PubMed
description Leptin is a peptide hormone produced by adipose tissue and acts in brain centers to control critical physiological functions. Leptin receptors are especially abundant in the hypothalamus and trigger specific neuronal subpopulations, and activate several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway. Although most studies focus on its role in energy intake and expenditure, leptin also plays a critical role in many central nervous system diseases.
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spelling pubmed-47828202016-03-28 The role of leptin in central nervous system diseases Li, Xiao-Mei Yan, Hai-Jing Guo, Yi-Shan Wang, Dong Neuroreport Clinical Neuroscience Leptin is a peptide hormone produced by adipose tissue and acts in brain centers to control critical physiological functions. Leptin receptors are especially abundant in the hypothalamus and trigger specific neuronal subpopulations, and activate several intracellular signaling events, including the JAK/STAT, MAPK, PI3K, and mTOR pathway. Although most studies focus on its role in energy intake and expenditure, leptin also plays a critical role in many central nervous system diseases. Lippincott Williams & Wilkins 2016-03-23 2016-03-09 /pmc/articles/PMC4782820/ /pubmed/26885866 http://dx.doi.org/10.1097/WNR.0000000000000546 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Clinical Neuroscience
Li, Xiao-Mei
Yan, Hai-Jing
Guo, Yi-Shan
Wang, Dong
The role of leptin in central nervous system diseases
title The role of leptin in central nervous system diseases
title_full The role of leptin in central nervous system diseases
title_fullStr The role of leptin in central nervous system diseases
title_full_unstemmed The role of leptin in central nervous system diseases
title_short The role of leptin in central nervous system diseases
title_sort role of leptin in central nervous system diseases
topic Clinical Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782820/
https://www.ncbi.nlm.nih.gov/pubmed/26885866
http://dx.doi.org/10.1097/WNR.0000000000000546
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