Visualization of APP and BACE-1 approximation in neurons: new insights into the amyloidogenic pathway

Cleavage of APP (amyloid precursor protein) by BACE-1 (β-site APP cleaving enzyme-1) is the rate-limiting step in amyloid-beta (Aβ) production and a neuropathologic hallmark of Alzheimer's disease (AD); thus physical approximation of this substrate-enzyme pair is a critical event with broad bio...

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Detalles Bibliográficos
Autores principales: Das, Utpal, Wang, Lina, Ganguly, Archan, Saikia, Junmi M., Wagner, Steven L., Koo, Edward H., Roy, Subhojit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782935/
https://www.ncbi.nlm.nih.gov/pubmed/26642089
http://dx.doi.org/10.1038/nn.4188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782935/
https://www.ncbi.nlm.nih.gov/pubmed/26642089
http://dx.doi.org/10.1038/nn.4188

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