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Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles

We evaluated adverse events, biodistribution and shedding of oncolytic vaccinia virus encoding CD40 ligand in two Beagles, in preparation for a phase 1 trial in canine cancer patients. Dog 1 received one dose of vaccinia virus and was euthanized 24 hours afterwards, while dog 2 received virus four t...

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Detalles Bibliográficos
Autores principales:	Autio, Karoliina, Knuuttila, Anna, Kipar, Anja, Pesonen, Sari, Guse, Kilian, Parviainen, Suvi, Rajamäki, Minna, Laitinen-Vapaavuori, Outi, Vähä-Koskela, Markus, Kanerva, Anna, Hemminki, Akseli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782937/ https://www.ncbi.nlm.nih.gov/pubmed/27119092 http://dx.doi.org/10.1038/mto.2014.2

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