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Reporter gene imaging identifies intratumoral infection voids as a critical barrier to systemic oncolytic virus efficacy
Systemically administered oncolytic viruses have the ability to cause tumor destruction through the expansion and coalescence of intratumoral infectious centers. Efficacy is therefore dependent upon both the density and intratumoral distribution of virus-infected cells achieved after initial virus i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782940/ https://www.ncbi.nlm.nih.gov/pubmed/27119095 http://dx.doi.org/10.1038/mto.2014.5 |