Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of metabolism, changes in TH signaling have widespre...

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Detalles Bibliográficos
Autores principales: Visser, W. Edward, Bombardieri, Cíntia R., Zevenbergen, Chantal, Barnhoorn, Sander, Ottaviani, Alexandre, van der Pluijm, Ingrid, Brandt, Renata, Kaptein, Ellen, van Heerebeek, Ramona, van Toor, Hans, Garinis, George A., Peeters, Robin P., Medici, Marco, van Ham, Willy, Vermeij, Wilbert P., de Waard, Monique C., de Krijger, Ronald R., Boelen, Anita, Kwakkel, Joan, Kopchick, John J., List, Edward O., Melis, Joost P. M., Darras, Veerle M., Dollé, Martijn E. T., van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., Visser, Theo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783069/
https://www.ncbi.nlm.nih.gov/pubmed/26953569
http://dx.doi.org/10.1371/journal.pone.0149941

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