Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear

Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF‐related apoptosis‐inducing ligand (TRAIL)...

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Autores principales: Kao, Shyan‐Yuan, Soares, Vitor Y.R., Kristiansen, Arthur G., Stankovic, Konstantina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783338/
https://www.ncbi.nlm.nih.gov/pubmed/26791792
http://dx.doi.org/10.1111/acel.12437
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author Kao, Shyan‐Yuan
Soares, Vitor Y.R.
Kristiansen, Arthur G.
Stankovic, Konstantina M.
author_facet Kao, Shyan‐Yuan
Soares, Vitor Y.R.
Kristiansen, Arthur G.
Stankovic, Konstantina M.
author_sort Kao, Shyan‐Yuan
collection PubMed
description Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF‐related apoptosis‐inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5‐blocking antibodies.
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spelling pubmed-47833382016-04-13 Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear Kao, Shyan‐Yuan Soares, Vitor Y.R. Kristiansen, Arthur G. Stankovic, Konstantina M. Aging Cell Original Articles Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF‐related apoptosis‐inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5‐blocking antibodies. John Wiley and Sons Inc. 2016-01-21 2016-04 /pmc/articles/PMC4783338/ /pubmed/26791792 http://dx.doi.org/10.1111/acel.12437 Text en © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Kao, Shyan‐Yuan
Soares, Vitor Y.R.
Kristiansen, Arthur G.
Stankovic, Konstantina M.
Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
title Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
title_full Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
title_fullStr Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
title_full_unstemmed Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
title_short Activation of TRAIL‐DR5 pathway promotes sensorineural degeneration in the inner ear
title_sort activation of trail‐dr5 pathway promotes sensorineural degeneration in the inner ear
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783338/
https://www.ncbi.nlm.nih.gov/pubmed/26791792
http://dx.doi.org/10.1111/acel.12437
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