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Mitochondrial metabolites extend lifespan

Disruption of mitochondrial respiration in the nematode Caenorhabditis elegans can extend lifespan. We previously showed that long‐lived respiratory mutants generate elevated amounts of α‐ketoacids. These compounds are structurally related to α‐ketoglutarate, suggesting they may be biologically rele...

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Detalles Bibliográficos
Autores principales:	Mishur, Robert J., Khan, Maruf, Munkácsy, Erin, Sharma, Lokendra, Bokov, Alex, Beam, Haley, Radetskaya, Oxana, Borror, Megan, Lane, Rebecca, Bai, Yidong, Rea, Shane L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783347/ https://www.ncbi.nlm.nih.gov/pubmed/26729005 http://dx.doi.org/10.1111/acel.12439

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