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Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells
Acute myeloid leukemia (AML) is a heterogeneous group of malignancies which incidence increases with age. The disease affects the differentiation of hematopoietic stem or precursor cells in the bone marrow and can be related to abnormal cytogenetic and/or specific mutational patterns. AML blasts can...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783386/ https://www.ncbi.nlm.nih.gov/pubmed/27014273 http://dx.doi.org/10.3389/fimmu.2016.00094 |
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author | Dulphy, Nicolas Chrétien, Anne-Sophie Khaznadar, Zena Fauriat, Cyril Nanbakhsh, Arash Caignard, Anne Chouaib, Salem Olive, Daniel Toubert, Antoine |
author_facet | Dulphy, Nicolas Chrétien, Anne-Sophie Khaznadar, Zena Fauriat, Cyril Nanbakhsh, Arash Caignard, Anne Chouaib, Salem Olive, Daniel Toubert, Antoine |
author_sort | Dulphy, Nicolas |
collection | PubMed |
description | Acute myeloid leukemia (AML) is a heterogeneous group of malignancies which incidence increases with age. The disease affects the differentiation of hematopoietic stem or precursor cells in the bone marrow and can be related to abnormal cytogenetic and/or specific mutational patterns. AML blasts can be sensitive to natural killer (NK) cell antitumor response. However, NK cells are frequently defective in AML patients leading to tumor escape. NK cell defects affect not only the expression of the activating NK receptors, including the natural cytotoxicity receptors, the NK group 2, member D, and the DNAX accessory molecule-1, but also cytotoxicity and IFN-γ release. Such perturbations in NK cell physiology could be related to the adaptation of the AML to the immune pressure and more generally to patient’s clinical features. Various mechanisms are potentially involved in the inhibition of NK-cell functions in AML, including defects in the normal lymphopoiesis, reduced expression of activating receptors through cell-to-cell contacts, and production of immunosuppressive soluble agents by leukemic blasts. Therefore, the continuous cross-talk between AML and NK cells participates to the leukemia immune escape and eventually to patient’s relapse. Methods to restore or stimulate NK cells seem to be attractive strategies to treat patients once the complete remission is achieved. Moreover, our capacity in stimulating the NK cell functions could lead to the development of preemptive strategies to eliminate leukemia-initiating cells before the emergence of the disease in elderly individuals presenting preleukemic mutations in hematopoietic stem cells. |
format | Online Article Text |
id | pubmed-4783386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47833862016-03-24 Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells Dulphy, Nicolas Chrétien, Anne-Sophie Khaznadar, Zena Fauriat, Cyril Nanbakhsh, Arash Caignard, Anne Chouaib, Salem Olive, Daniel Toubert, Antoine Front Immunol Immunology Acute myeloid leukemia (AML) is a heterogeneous group of malignancies which incidence increases with age. The disease affects the differentiation of hematopoietic stem or precursor cells in the bone marrow and can be related to abnormal cytogenetic and/or specific mutational patterns. AML blasts can be sensitive to natural killer (NK) cell antitumor response. However, NK cells are frequently defective in AML patients leading to tumor escape. NK cell defects affect not only the expression of the activating NK receptors, including the natural cytotoxicity receptors, the NK group 2, member D, and the DNAX accessory molecule-1, but also cytotoxicity and IFN-γ release. Such perturbations in NK cell physiology could be related to the adaptation of the AML to the immune pressure and more generally to patient’s clinical features. Various mechanisms are potentially involved in the inhibition of NK-cell functions in AML, including defects in the normal lymphopoiesis, reduced expression of activating receptors through cell-to-cell contacts, and production of immunosuppressive soluble agents by leukemic blasts. Therefore, the continuous cross-talk between AML and NK cells participates to the leukemia immune escape and eventually to patient’s relapse. Methods to restore or stimulate NK cells seem to be attractive strategies to treat patients once the complete remission is achieved. Moreover, our capacity in stimulating the NK cell functions could lead to the development of preemptive strategies to eliminate leukemia-initiating cells before the emergence of the disease in elderly individuals presenting preleukemic mutations in hematopoietic stem cells. Frontiers Media S.A. 2016-03-09 /pmc/articles/PMC4783386/ /pubmed/27014273 http://dx.doi.org/10.3389/fimmu.2016.00094 Text en Copyright © 2016 Dulphy, Chrétien, Khaznadar, Fauriat, Nanbakhsh, Caignard, Chouaib, Olive and Toubert. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Dulphy, Nicolas Chrétien, Anne-Sophie Khaznadar, Zena Fauriat, Cyril Nanbakhsh, Arash Caignard, Anne Chouaib, Salem Olive, Daniel Toubert, Antoine Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells |
title | Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells |
title_full | Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells |
title_fullStr | Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells |
title_full_unstemmed | Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells |
title_short | Underground Adaptation to a Hostile Environment: Acute Myeloid Leukemia vs. Natural Killer Cells |
title_sort | underground adaptation to a hostile environment: acute myeloid leukemia vs. natural killer cells |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783386/ https://www.ncbi.nlm.nih.gov/pubmed/27014273 http://dx.doi.org/10.3389/fimmu.2016.00094 |
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