Elevated Neuronal Excitability Due to Modulation of the Voltage-Gated Sodium Channel Nav1.6 by Aβ(1−42)

Aberrant increases in neuronal network excitability may contribute to the cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability are not fully understood. Such overexcitation of neuronal networks has been detected in the brains of APP/PS1 mice. In t...

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Detalles Bibliográficos
Autores principales: Wang, Xi, Zhang, Xiao-Gang, Zhou, Ting-Ting, Li, Na, Jang, Chun-Yan, Xiao, Zhi-Cheng, Ma, Quan-Hong, Li, Shao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783403/
https://www.ncbi.nlm.nih.gov/pubmed/27013956
http://dx.doi.org/10.3389/fnins.2016.00094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783403/
https://www.ncbi.nlm.nih.gov/pubmed/27013956
http://dx.doi.org/10.3389/fnins.2016.00094

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