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Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma

Few preoperative extrapontine myelinolysis (EPM) cases with pituitary adenoma have been reported. No such case had long follow-up to see the outcome of EPM. We reported a 38-year-old man complaining of nausea, malaise and transient loss of consciousness who was found to have severe hyponatremia. Neu...

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Autores principales: Zhou, Ying, Zhu, Yicheng, Wang, Wenze, Xing, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Neurosurgical Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783484/
https://www.ncbi.nlm.nih.gov/pubmed/26962424
http://dx.doi.org/10.3340/jkns.2016.59.2.161
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author Zhou, Ying
Zhu, Yicheng
Wang, Wenze
Xing, Bing
author_facet Zhou, Ying
Zhu, Yicheng
Wang, Wenze
Xing, Bing
author_sort Zhou, Ying
collection PubMed
description Few preoperative extrapontine myelinolysis (EPM) cases with pituitary adenoma have been reported. No such case had long follow-up to see the outcome of EPM. We reported a 38-year-old man complaining of nausea, malaise and transient loss of consciousness who was found to have severe hyponatremia. Neurologic deficits including altered mental status, behavioral disturbances, dysarthria and dysphagia developed despite slow correction of hyponatremia. Endocrine and imaging studies revealed hypopituitarism, nonfunctional pituitary macroadenoma and extrapontine myelinolysis. Transsphenoidal surgery was performed after three weeks of supportive therapy, when neurological symptoms improved significantly. The patient recovered function completely 3 months after surgery. Our case indicates that outcome of EPM can be good even with prolonged periods of severe neurologic impairment.
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spelling pubmed-47834842016-03-09 Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma Zhou, Ying Zhu, Yicheng Wang, Wenze Xing, Bing J Korean Neurosurg Soc Case Report Few preoperative extrapontine myelinolysis (EPM) cases with pituitary adenoma have been reported. No such case had long follow-up to see the outcome of EPM. We reported a 38-year-old man complaining of nausea, malaise and transient loss of consciousness who was found to have severe hyponatremia. Neurologic deficits including altered mental status, behavioral disturbances, dysarthria and dysphagia developed despite slow correction of hyponatremia. Endocrine and imaging studies revealed hypopituitarism, nonfunctional pituitary macroadenoma and extrapontine myelinolysis. Transsphenoidal surgery was performed after three weeks of supportive therapy, when neurological symptoms improved significantly. The patient recovered function completely 3 months after surgery. Our case indicates that outcome of EPM can be good even with prolonged periods of severe neurologic impairment. The Korean Neurosurgical Society 2016-03 2016-02-29 /pmc/articles/PMC4783484/ /pubmed/26962424 http://dx.doi.org/10.3340/jkns.2016.59.2.161 Text en Copyright © 2016 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zhou, Ying
Zhu, Yicheng
Wang, Wenze
Xing, Bing
Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma
title Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma
title_full Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma
title_fullStr Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma
title_full_unstemmed Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma
title_short Preoperative Extrapontine Myelinolysis with Good Outcome in a Patient with Pituitary Adenoma
title_sort preoperative extrapontine myelinolysis with good outcome in a patient with pituitary adenoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783484/
https://www.ncbi.nlm.nih.gov/pubmed/26962424
http://dx.doi.org/10.3340/jkns.2016.59.2.161
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