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Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes
Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the anticodon and the loss of the ancestral tRNA gene. The net effect is a functional tRNA that is more closely related to t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783518/ https://www.ncbi.nlm.nih.gov/pubmed/26227972 http://dx.doi.org/10.1093/nar/gkv746 |
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author | Sahyoun, Abdullah H. Hölzer, Martin Jühling, Frank Höner zu Siederdissen, Christian Al-Arab, Marwa Tout, Kifah Marz, Manja Middendorf, Martin Stadler, Peter F. Bernt, Matthias |
author_facet | Sahyoun, Abdullah H. Hölzer, Martin Jühling, Frank Höner zu Siederdissen, Christian Al-Arab, Marwa Tout, Kifah Marz, Manja Middendorf, Martin Stadler, Peter F. Bernt, Matthias |
author_sort | Sahyoun, Abdullah H. |
collection | PubMed |
description | Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the anticodon and the loss of the ancestral tRNA gene. The net effect is a functional tRNA that is more closely related to tRNAs of a different alloacceptor family than to tRNAs with the same anticodon in related species. Beyond being of interest for understanding mitochondrial tRNA function and evolution, tRNA remolding events can lead to artifacts in the annotation of mitogenomes and thus in studies of mitogenomic evolution. Therefore, it is important to identify and catalog these events. Here we describe novel methods to detect tRNA remolding in large-scale data sets and apply them to survey tRNA remolding throughout animal evolution. We identify several novel remolding events in addition to the ones previously mentioned in the literature. A detailed analysis of these remoldings showed that many of them are derived from ancestral events. |
format | Online Article Text |
id | pubmed-4783518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47835182016-03-10 Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes Sahyoun, Abdullah H. Hölzer, Martin Jühling, Frank Höner zu Siederdissen, Christian Al-Arab, Marwa Tout, Kifah Marz, Manja Middendorf, Martin Stadler, Peter F. Bernt, Matthias Nucleic Acids Res RNA Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the anticodon and the loss of the ancestral tRNA gene. The net effect is a functional tRNA that is more closely related to tRNAs of a different alloacceptor family than to tRNAs with the same anticodon in related species. Beyond being of interest for understanding mitochondrial tRNA function and evolution, tRNA remolding events can lead to artifacts in the annotation of mitogenomes and thus in studies of mitogenomic evolution. Therefore, it is important to identify and catalog these events. Here we describe novel methods to detect tRNA remolding in large-scale data sets and apply them to survey tRNA remolding throughout animal evolution. We identify several novel remolding events in addition to the ones previously mentioned in the literature. A detailed analysis of these remoldings showed that many of them are derived from ancestral events. Oxford University Press 2015-09-18 2015-07-30 /pmc/articles/PMC4783518/ /pubmed/26227972 http://dx.doi.org/10.1093/nar/gkv746 Text en © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RNA Sahyoun, Abdullah H. Hölzer, Martin Jühling, Frank Höner zu Siederdissen, Christian Al-Arab, Marwa Tout, Kifah Marz, Manja Middendorf, Martin Stadler, Peter F. Bernt, Matthias Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes |
title | Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes |
title_full | Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes |
title_fullStr | Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes |
title_full_unstemmed | Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes |
title_short | Towards a comprehensive picture of alloacceptor tRNA remolding in metazoan mitochondrial genomes |
title_sort | towards a comprehensive picture of alloacceptor trna remolding in metazoan mitochondrial genomes |
topic | RNA |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783518/ https://www.ncbi.nlm.nih.gov/pubmed/26227972 http://dx.doi.org/10.1093/nar/gkv746 |
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