The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic...

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Autores principales: Bimonte, Sabrina, Barbieri, Antonio, Leongito, Maddalena, Palma, Giuseppe, del Vecchio, Vitale, Falco, Michela, Palaia, Raffaele, Albino, Vittorio, Piccirillo, Mauro, Amore, Alfonso, Petrillo, Antonella, Granata, Vincenza, Izzo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783541/
https://www.ncbi.nlm.nih.gov/pubmed/27006664
http://dx.doi.org/10.1155/2016/8352684
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author Bimonte, Sabrina
Barbieri, Antonio
Leongito, Maddalena
Palma, Giuseppe
del Vecchio, Vitale
Falco, Michela
Palaia, Raffaele
Albino, Vittorio
Piccirillo, Mauro
Amore, Alfonso
Petrillo, Antonella
Granata, Vincenza
Izzo, Francesco
author_facet Bimonte, Sabrina
Barbieri, Antonio
Leongito, Maddalena
Palma, Giuseppe
del Vecchio, Vitale
Falco, Michela
Palaia, Raffaele
Albino, Vittorio
Piccirillo, Mauro
Amore, Alfonso
Petrillo, Antonella
Granata, Vincenza
Izzo, Francesco
author_sort Bimonte, Sabrina
collection PubMed
description Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.
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spelling pubmed-47835412016-03-22 The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells Bimonte, Sabrina Barbieri, Antonio Leongito, Maddalena Palma, Giuseppe del Vecchio, Vitale Falco, Michela Palaia, Raffaele Albino, Vittorio Piccirillo, Mauro Amore, Alfonso Petrillo, Antonella Granata, Vincenza Izzo, Francesco Stem Cells Int Review Article Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells. Hindawi Publishing Corporation 2016 2016-02-24 /pmc/articles/PMC4783541/ /pubmed/27006664 http://dx.doi.org/10.1155/2016/8352684 Text en Copyright © 2016 Sabrina Bimonte et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bimonte, Sabrina
Barbieri, Antonio
Leongito, Maddalena
Palma, Giuseppe
del Vecchio, Vitale
Falco, Michela
Palaia, Raffaele
Albino, Vittorio
Piccirillo, Mauro
Amore, Alfonso
Petrillo, Antonella
Granata, Vincenza
Izzo, Francesco
The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
title The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
title_full The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
title_fullStr The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
title_full_unstemmed The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
title_short The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells
title_sort role of mirnas in the regulation of pancreatic cancer stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783541/
https://www.ncbi.nlm.nih.gov/pubmed/27006664
http://dx.doi.org/10.1155/2016/8352684
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