Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation

Objectives. To ascertain if mitochondrial dysfunction (MD) of kidney cells is present in severe hemorrhagic shock and to investigate whether polydatin (PD) can attenuate MD and its protective mechanisms. Research Design and Methods. Renal tubular epithelial cells (RTECs) from rat kidneys experiencin...

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Detalles Bibliográficos
Autores principales: Zeng, Zhenhua, Chen, Zhongqing, Xu, Siqi, Zhang, Qin, Wang, Xingmin, Gao, Youguang, Zhao, Ke-seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783550/
https://www.ncbi.nlm.nih.gov/pubmed/27057271
http://dx.doi.org/10.1155/2016/1737185

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