Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction

Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to t...

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Autores principales: Alnasrallah, Basil, Collins, John F., Zwi, L. Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783551/
https://www.ncbi.nlm.nih.gov/pubmed/27006842
http://dx.doi.org/10.1155/2016/4162674
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author Alnasrallah, Basil
Collins, John F.
Zwi, L. Jonathan
author_facet Alnasrallah, Basil
Collins, John F.
Zwi, L. Jonathan
author_sort Alnasrallah, Basil
collection PubMed
description Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy.
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spelling pubmed-47835512016-03-22 Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction Alnasrallah, Basil Collins, John F. Zwi, L. Jonathan Case Rep Nephrol Case Report Kidney injury in the context of cholestatic liver dysfunction is not uncommon; this has been historically referred to as cholemic nephrosis implying a direct deleterious renal effect of cholemia. However, scepticism about the exact role that bile and its constituents play in this injury has led to the disappearance of the term. We describe a case of severe AKI due to bile nephropathy with bile casts in flucloxacillin-induced liver dysfunction. We also discuss the recent literature reviving the concept of bile nephropathy. Hindawi Publishing Corporation 2016 2016-02-24 /pmc/articles/PMC4783551/ /pubmed/27006842 http://dx.doi.org/10.1155/2016/4162674 Text en Copyright © 2016 Basil Alnasrallah et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alnasrallah, Basil
Collins, John F.
Zwi, L. Jonathan
Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
title Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
title_full Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
title_fullStr Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
title_full_unstemmed Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
title_short Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
title_sort bile nephropathy in flucloxacillin-induced cholestatic liver dysfunction
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783551/
https://www.ncbi.nlm.nih.gov/pubmed/27006842
http://dx.doi.org/10.1155/2016/4162674
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