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Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice

Anxiety and depressive symptoms are generated after paradoxical sleep deprivation (PSD). However, it is not clear whether PSD produces differential effects between females and males. The aim of this study was to assess the effect of PSD on anxiety- and depressive-like behaviors between sexes. Male a...

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Autores principales: Gonzalez-Castañeda, Rocio E., Galvez-Contreras, Alma Y., Martínez-QUEZADA, Carlos J., Jauregui-Huerta, Fernando, Grcia-Estrada, Joaquin, Ramos-Zuñiga, Luquin, Gonzalez-Perez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783655/
https://www.ncbi.nlm.nih.gov/pubmed/26548630
http://dx.doi.org/10.1538/expanim.15-0054
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author Gonzalez-Castañeda, Rocio E.
Galvez-Contreras, Alma Y.
Martínez-QUEZADA, Carlos J.
Jauregui-Huerta, Fernando
Grcia-Estrada, Joaquin
Ramos-Zuñiga,
Luquin,
Gonzalez-Perez,
author_facet Gonzalez-Castañeda, Rocio E.
Galvez-Contreras, Alma Y.
Martínez-QUEZADA, Carlos J.
Jauregui-Huerta, Fernando
Grcia-Estrada, Joaquin
Ramos-Zuñiga,
Luquin,
Gonzalez-Perez,
author_sort Gonzalez-Castañeda, Rocio E.
collection PubMed
description Anxiety and depressive symptoms are generated after paradoxical sleep deprivation (PSD). However, it is not clear whether PSD produces differential effects between females and males. The aim of this study was to assess the effect of PSD on anxiety- and depressive-like behaviors between sexes. Male and female BALB/c mice were divided in three groups: the control group, the 48-h PSD group and the 96-h PSD group. Immediately after PSD protocols, the forced swimming and open field test were applied. Sucrose consumption test was used to evaluate the middle-term effect of PSD. We found that corticosterone serum levels showed significant differences in the 96-h PSD females as compared to 96-h PSD males. In the open-field test, the 48-h and 96-h PSD females spent more time at the periphery of the field, and showed high locomotion as compared to males. In the elevated plus maze, the 48-h PSD females spent more time in closed arms than males, which is compatible with anxiety-like behavior. The forced swim test indicated that the 96-h PSD males spent more time swimming as compared to the 96-h PSD females. Remarkably, the 96-h PSD males had lower sucrose intake than the 96-h PSD females, which suggest that male mice have proclivity to develop a persistent depressive-like behavior late after PSD. In conclusion, male mice showed a significant trend to depressive-like behaviors late after sleep deprivation. Conversely, female have a strong tendency to display anxiety- and depressive-like behaviors immediately after sleep deprivation.
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spelling pubmed-47836552016-03-10 Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice Gonzalez-Castañeda, Rocio E. Galvez-Contreras, Alma Y. Martínez-QUEZADA, Carlos J. Jauregui-Huerta, Fernando Grcia-Estrada, Joaquin Ramos-Zuñiga, Luquin, Gonzalez-Perez, Exp Anim Original Anxiety and depressive symptoms are generated after paradoxical sleep deprivation (PSD). However, it is not clear whether PSD produces differential effects between females and males. The aim of this study was to assess the effect of PSD on anxiety- and depressive-like behaviors between sexes. Male and female BALB/c mice were divided in three groups: the control group, the 48-h PSD group and the 96-h PSD group. Immediately after PSD protocols, the forced swimming and open field test were applied. Sucrose consumption test was used to evaluate the middle-term effect of PSD. We found that corticosterone serum levels showed significant differences in the 96-h PSD females as compared to 96-h PSD males. In the open-field test, the 48-h and 96-h PSD females spent more time at the periphery of the field, and showed high locomotion as compared to males. In the elevated plus maze, the 48-h PSD females spent more time in closed arms than males, which is compatible with anxiety-like behavior. The forced swim test indicated that the 96-h PSD males spent more time swimming as compared to the 96-h PSD females. Remarkably, the 96-h PSD males had lower sucrose intake than the 96-h PSD females, which suggest that male mice have proclivity to develop a persistent depressive-like behavior late after PSD. In conclusion, male mice showed a significant trend to depressive-like behaviors late after sleep deprivation. Conversely, female have a strong tendency to display anxiety- and depressive-like behaviors immediately after sleep deprivation. Japanese Association for Laboratory Animal Science 2015-11-06 2016 /pmc/articles/PMC4783655/ /pubmed/26548630 http://dx.doi.org/10.1538/expanim.15-0054 Text en ©2016 Japanese Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Original
Gonzalez-Castañeda, Rocio E.
Galvez-Contreras, Alma Y.
Martínez-QUEZADA, Carlos J.
Jauregui-Huerta, Fernando
Grcia-Estrada, Joaquin
Ramos-Zuñiga,
Luquin,
Gonzalez-Perez,
Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
title Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
title_full Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
title_fullStr Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
title_full_unstemmed Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
title_short Sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
title_sort sex-related effects of sleep deprivation on depressive- and anxiety-like behaviors in mice
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783655/
https://www.ncbi.nlm.nih.gov/pubmed/26548630
http://dx.doi.org/10.1538/expanim.15-0054
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