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A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

The RNA-dependent RNA polymerase of influenza A virus comprises conserved and independently-folded subdomains with defined functionalities. The N-terminal domain of the PA subunit (PA(N)) harbors the endonuclease function so that it can serve as a desired target for drug discovery. To identify a cla...

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Detalles Bibliográficos
Autores principales:	Yuan, Shuofeng, Chu, Hin, Singh, Kailash, Zhao, Hanjun, Zhang, Ke, Kao, Richard Y. T., Chow, Billy K. C., Zhou, Jie, Zheng, Bo-Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783701/ https://www.ncbi.nlm.nih.gov/pubmed/26956222 http://dx.doi.org/10.1038/srep22880

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